Basic Information

Symbol
CDKN2B-AS1
RNA class
lncRNA
Alias
AL449423.1 ANRIL CDKN2B-AS CDKN2BAS ENSG00000240498.2 ENSG00000240498.6 ENSG00000240498.7 ENSG00000266446.1 NCRNA00089 OTTHUMG00000019689.3 OTTHUMG00000179348.1 PCAT12 RP11-145E5.4 RP11-149I2.4 p15AS
Location (GRCh38)
9:21994778-22239122
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
CDKN2B-AS1:5 AGCUACAUCCGUCACCUGACACGGCCCUACCAGGAACAGCCGCGCUCCC… 1337 nt 0.4405
CDKN2B-AS1:50 AUCCGUCACCUGACACGGCCCUACCAGGAACAGCCGCGCUCCCGCGGAU… 1061 nt 0.4656
CDKN2B-AS1:51 AUCCGUCACCUGACACGGCCCUACCAGGAACAGCCGCGCUCCCGCGGAU… 850 nt 0.4471
CDKN2B-AS1:52 AUCCGUCACCUGACACGGCCCUACCAGGAACAGCCGCGCUCCCGCGGAU… 2654 nt 0.4424
CDKN2B-AS1:53 AUCCGUCACCUGACACGGCCCUACCAGGAACAGCCGCGCUCCCGCGGAU… 918 nt 0.4575
CDKN2B-AS1:54 AUCCGUCACCUGACACGGCCCUACCAGGAACAGCCGCGCUCCCGCGGAU… 1054 nt 0.4706
CDKN2B-AS1:55 AUCCGUCACCUGACACGGCCCUACCAGGAACAGCCGCGCUCCCGCGGAU… 707 nt 0.4682
CDKN2B-AS1:56 AUCCGUCACCUGACACGGCCCUACCAGGAACAGCCGCGCUCCCGCGGAU… 2169 nt 0.4426
CDKN2B-AS1:57 AUCCGUCACCUGACACGGCCCUACCAGGAACAGCCGCGCUCCCGCGGAU… 3829 nt 0.4244
CDKN2B-AS1:58 AUCCGUCACCUGACACGGCCCUACCAGGAACAGCCGCGCUCCCGCGGAU… 500 nt 0.5400
Showing 41 to 50 of 74 entries
Summary

This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014]

Forensic Context

A study in humans demonstrated that the CDKN2B-AS1 (ANRIL) was significantly upregulated in the plasma of coronary artery disease patients and showed significant diagnostic predictive value with an AUC of 0.82 in ROC analysis [Abdallah et al. DOI:10.1007/s40291-022-00622-1]. A review of studies in humans, mice, and rats indicates that the CDKN2B-AS1 is involved in atherosclerosis formation in coronary artery disease [Tian et al. DOI:10.3390/molecules26041155].