Basic Information

Symbol
CDKN2B-AS1
RNA class
lncRNA
Alias
AL449423.1 ANRIL CDKN2B-AS CDKN2BAS ENSG00000240498.2 ENSG00000240498.6 ENSG00000240498.7 ENSG00000266446.1 NCRNA00089 OTTHUMG00000019689.3 OTTHUMG00000179348.1 PCAT12 RP11-145E5.4 RP11-149I2.4 p15AS
Location (GRCh38)
9:21994778-22239122
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
CDKN2B-AS1:59 AAACCGCUGCACGCCUCUGACGCGACAUCUGGACACGGCGCGGCGCUGG… 723 nt 0.4661
CDKN2B-AS1:6 AGCUACAUCCGUCACCUGACACGGCCCUACCAGGAACAGCCGCGCUCCC… 1260 nt 0.4611
CDKN2B-AS1:60 AAACCGCUGCACGCCUCUGACGCGACAUCUGGACACGGCGCGGCGCUGG… 710 nt 0.4535
CDKN2B-AS1:61 AAACCGCUGCACGCCUCUGACGCGACAUCUGGACACGGCGCGGCGCUGG… 738 nt 0.4824
CDKN2B-AS1:62 AAACCGCUGCACGCCUCUGACGCGACAUCUGGACACGGCGCGGCGCUGG… 500 nt 0.4620
CDKN2B-AS1:63 GACUCCCCUUGAUCCCGCCGCCUGACUCCUCGGCCUGGGAGACAGGAAA… 445 nt 0.6719
CDKN2B-AS1:64 GACUCCCCUUGAUCCCGCCGCCUGACUCCUCGGCGUACGUUCUCUCUCC… 1772 nt 0.5226
CDKN2B-AS1:65 GACUCCCCUUGAUCCCGCCGCCUGACUCCUCGGCGUACGUUCUCUCUCC… 845 nt 0.5231
CDKN2B-AS1:66 GAUCCCGCCGCCUGACUCCUCGGCCUGGGAGACAGGAAAAGCGGUCCUG… 435 nt 0.6736
CDKN2B-AS1:67 AGCUACAUCCGUCACCUGACACGGCCCUACCAGGAACAGCCGCGCUCCC… 1785 nt 0.4213
Showing 51 to 60 of 74 entries
Summary

This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014]

Forensic Context

A study in humans demonstrated that the CDKN2B-AS1 (ANRIL) was significantly upregulated in the plasma of coronary artery disease patients and showed significant diagnostic predictive value with an AUC of 0.82 in ROC analysis [Abdallah et al. DOI:10.1007/s40291-022-00622-1]. A review of studies in humans, mice, and rats indicates that the CDKN2B-AS1 is involved in atherosclerosis formation in coronary artery disease [Tian et al. DOI:10.3390/molecules26041155].