Basic Information

Symbol
LINC-ROR
RNA class
lncRNA
Alias
CTD-2526M8.1 ENSG00000258609 ENSG00000258609.1 ENSG00000258609.2 ENSG00000258609.3 OTTHUMG00000171587.1 ROR lincRNA-RoR lincRNA-ST8SIA3
Location (GRCh38)
18:57054558-57072119
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
LINC-ROR:1 GGUGAAAUAAACAGCCAUGUUGCUCACACAAAGCCUGUUUGGUGGUCUC… 2580 nt 0.4589
LINC-ROR:10 AUUUGGUGAUGUGACUCGGAUAGGGGGACCUCCCUUGGGAGAUCAGUAC… 568 nt 0.5070
LINC-ROR:11 GACCCCACUGGAAAUCGGACUGUCCAACUCACCUGACAGCCACUCCCAC… 737 nt 0.5088
LINC-ROR:12 GACCCCACUGGAAAUCGGACUGUCCAACUCACCUGACAGCCACUCCCAC… 544 nt 0.5092
LINC-ROR:13 GACCCCACUGGAAAUCGGACUGUCCAACUCACCUGACAGCCACUCCCAC… 532 nt 0.5056
LINC-ROR:2 GGUGAAAUAAACAGCCAUGUUGCUCACACAAAGCCUGUUUGGUGGUCUC… 2591 nt 0.4570
LINC-ROR:3 GGUGAAAUAAACAGCCAUGUUGCUCACACAAAGCCUGUUUGGUGGUCUC… 2589 nt 0.4573
LINC-ROR:4 GGUGAAAUAAACAGCCAUGUUGCUCACACAAAGCCUGUUUGGUGGUCUC… 2603 nt 0.4568
LINC-ROR:5 AAGAAGUGAAAAUGCCCUGCCCCGCCUUAACUGAUGACAUUCCACCACA… 645 nt 0.4450
LINC-ROR:6 GGUGAAAUAAACAGCCAUGUUGCUCACACAAAGCCUGUUUGGUGGUCUC… 2604 nt 0.4566
Showing 1 to 10 of 13 entries
Summary

This gene produces a long non-coding RNA that regulates the reprogramming of pluripotent stem cells. This RNA suppresses induction of tumor protein p53 after DNA damage. It is thought to act as a sponge for microRNAs that regulate stem cell factors POU class 5 homeobox 1, Nanog, and SRY-box 2. This RNA may also have a extracellular role in modulating response to hypoxia in hepatocellular cancer cells. Expression of this transcript is associated with tumor progression and epithelial to mesenchymal transition and metastasis. [provided by RefSeq, Dec 2017]

Forensic Context

A study in human and mouse cells demonstrated that the LINC-ROR is important for reprogramming fibroblasts to induced pluripotent stem cells (iPSCs) and functions as a competing endogenous RNA (ceRNA) for specific microRNAs, including miR-145-5p, 181a-5p, and 99b-3p, which regulate core pluripotency factors [Flynn et al. DOI:10.1016/j.stem.2014.05.014]. A study in mice and human cells demonstrated that the LINC-ROR is important for reprogramming fibroblasts to induced pluripotent stem cells (iPSCs) and acts as a competing endogenous RNA (ceRNA) for miR-145-5p, miR-181a-5p, and miR-99b-3p, which regulate core pluripotency factors [Flynn and Chang DOI:10.1016/j.stem.2014.05.014]. In cardiovascular contexts, research in mice indicated the LINC-ROR promotes cardiac hypertrophy by sponging miR-133 to upregulate fetal genes and cardiomyocyte growth [Yeh et al. DOI:10.1186/s12929-020-00647-w].