Basic Information
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| LINC-ROR:7 | GGUGAAAUAAACAGCCAUGUUGCUCACACAAAGCCUGUUUGGUGGUCUC… | 766 nt | 0.5287 |
| LINC-ROR:8 | GCUCAUGAAAUUUGGUGAUGUGACUCGGAUAGGGGGACCUCCCUUGGGA… | 935 nt | 0.4610 |
| LINC-ROR:9 | GCUCAUGAAAUUUGGUGAUGUGACUCGGAUAGGGGGACCUCCCUUGGGA… | 2186 nt | 0.4675 |
Summary
This gene produces a long non-coding RNA that regulates the reprogramming of pluripotent stem cells. This RNA suppresses induction of tumor protein p53 after DNA damage. It is thought to act as a sponge for microRNAs that regulate stem cell factors POU class 5 homeobox 1, Nanog, and SRY-box 2. This RNA may also have a extracellular role in modulating response to hypoxia in hepatocellular cancer cells. Expression of this transcript is associated with tumor progression and epithelial to mesenchymal transition and metastasis. [provided by RefSeq, Dec 2017]
Forensic Context
A study in human and mouse cells demonstrated that the LINC-ROR is important for reprogramming fibroblasts to induced pluripotent stem cells (iPSCs) and functions as a competing endogenous RNA (ceRNA) for specific microRNAs, including miR-145-5p, 181a-5p, and 99b-3p, which regulate core pluripotency factors [Flynn et al. DOI:10.1016/j.stem.2014.05.014]. A study in mice and human cells demonstrated that the LINC-ROR is important for reprogramming fibroblasts to induced pluripotent stem cells (iPSCs) and acts as a competing endogenous RNA (ceRNA) for miR-145-5p, miR-181a-5p, and miR-99b-3p, which regulate core pluripotency factors [Flynn and Chang DOI:10.1016/j.stem.2014.05.014]. In cardiovascular contexts, research in mice indicated the LINC-ROR promotes cardiac hypertrophy by sponging miR-133 to upregulate fetal genes and cardiomyocyte growth [Yeh et al. DOI:10.1186/s12929-020-00647-w].