Basic Information

Symbol
lnc-BBOX1-10
RNA class
lncRNA
Alias
BDNF-AS
Location (GRCh38)
11:27463388-27596583
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
lnc-BBOX1-10:1 AAUCAAAUGAGAUAAAUAGCAGAAAUAGCAGAGAAGGGAUGAAAACUGA… 358 nt 0.4134
Summary

No relevant information is available at the moment.

Forensic Context

The long non-coding RNA BDNF-AS is identified as a therapeutic target in Alzheimer's disease and schizophrenia, where it functions by targeting BDNF, GDNF, and EPHB2 [Das et al. DOI:10.1080/21655979.2021.2003667]. A study in humans demonstrated that the expression of six long noncoding RNAs in peripheral blood mononuclear cells was significantly down-regulated in patients with major depressive disorder compared to healthy controls, with further significant reductions observed in patients exhibiting suicidal ideation or a past suicide attempt [Cui et al. DOI:10.1002/brb3.711].