Basic Information

Symbol
DIO3OS
RNA class
lncRNA
Alias
DIO3-AS1 Dio3as ENSG00000251028 ENSG00000258498 ENSG00000258498.1 ENSG00000258498.2 ENSG00000258498.6 ENSG00000258498.7 ENSG00000258498.8 NCRNA00041 OTTHUMG00000171682.1
Location (GRCh38)
14:101552221-101560431
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
DIO3OS:1 CCCCUCUCGCCGCUUGCCUCGCCCAGCGCAGCCCCGGCCGCUGGGCGCA… 1937 nt 0.6376
DIO3OS:10 CCCGGACGUUGCUCUCUACCCCGGGAACGUCGAGACUGGAGCGCCCGAA… 1639 nt 0.6211
DIO3OS:11 CCCGGGAACGUCGAGACUGGAGCGCCCGAACUGAGCCACCUUCGCGGAC… 1041 nt 0.6350
DIO3OS:12 CGCGGACCCCGAGAGCGGCGGCGCGACUCACCGCGGAGGCGCCCGGACG… 789 nt 0.6527
DIO3OS:13 GGUGCCUUGACCUAGGGACCCAGAGGCCGGGAGCAAGUCUCCUUUCGCC… 1809 nt 0.6274
DIO3OS:14 GGUGCCUUGACCUAGGGACCCAGAGGCCGGGAGCAAGUCUCCUUUCGCC… 2774 nt 0.6139
DIO3OS:15 AGCUGGCUGGGCUCGGUAGAGCGCGGGCGAAUCGCUUUCGGCAGCGAAG… 1421 nt 0.5848
DIO3OS:16 AAAGCAGCCUUUCUUUAGGGCUGUCAUCUGUUCUGGGGAUCUGUUGCUG… 401 nt 0.5761
DIO3OS:17 CUUCCCUCUGGGGUGGGGUGGGUUCUGGUGGCCCUGUGUUCCCCUGCAG… 413 nt 0.6199
DIO3OS:18 AGUGGAUUUCAGGAUUCCUCUAAGAAGCUUUGGAAUGCCAGAAGAUACC… 2473 nt 0.5459
Showing 1 to 10 of 31 entries
Summary

The mouse and human DIO3OS and DIO3 (MIM 601038) genes overlap and are transcribed in opposite directions. The mouse Dio3 gene is imprinted from the paternal allele during fetal development, suggesting that DIO3OS is a noncoding gene that may have a role in maintaining monoallelic expression of DIO3 (Hernandez et al., 2004 [PubMed 14962667]).[supplied by OMIM, Mar 2008]

Forensic Context

A study in mice demonstrated that the DIO3OS was identified as a significantly downregulated RNA marker (0.512-fold reduction) in lung tissue following hypothermia-induced death, classifying it as a candidate forensic biomarker for this condition [Takamiya et al. DOI:10.1016/J.Legalmed.2020.101789].