Basic Information

Symbol
DIO3OS
RNA class
lncRNA
Alias
DIO3-AS1 Dio3as ENSG00000251028 ENSG00000258498 ENSG00000258498.1 ENSG00000258498.2 ENSG00000258498.6 ENSG00000258498.7 ENSG00000258498.8 NCRNA00041 OTTHUMG00000171682.1
Location (GRCh38)
14:101552221-101560431
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
DIO3OS:19 AGUGGAUUUCAGGAUUCCUCUAAGAAGCUUUGGAAUGCCAGAAGAUACC… 985 nt 0.5513
DIO3OS:2 CCGCUUGCCUCGCCCAGCGCAGCCCCGGCCGCUGGGCGCACCCGUCCCG… 1702 nt 0.6257
DIO3OS:20 AGUGGAUUUCAGGAUUCCUCUAAGAAGCUUUGGAAUGCCAGAAGAUACC… 3455 nt 0.5632
DIO3OS:21 AGUGGAUUUCAGGAUUCCUCUAAGAAGCUUUGGAAUGCCAGAAGAUACC… 3454 nt 0.5634
DIO3OS:22 GCUGGGCGCACCCGUCCCGUUCGUCCCCGGACGUUGCUCUCUACCCCGG… 675 nt 0.5926
DIO3OS:23 GCUGGGCGCACCCGUCCCGUUCGUCCCCGGACGUUGCUCUCUACCCCGG… 3089 nt 0.6235
DIO3OS:24 GCUGGGCGCACCCGUCCCGUUCGUCCCCGGACGUUGCUCUCUACCCCGG… 1672 nt 0.6220
DIO3OS:25 GCUGGGCGCACCCGUCCCGUUCGUCCCCGGACGUUGCUCUCUACCCCGG… 875 nt 0.6560
DIO3OS:26 GCUGGGCGCACCCGUCCCGUUCGUCCCCGGACGUUGCUCUCUACCCCGG… 579 nt 0.7064
DIO3OS:27 GCUGGGCGCACCCGUCCCGUUCGUCCCCGGACGUUGCUCUCUACCCCGG… 5073 nt 0.5890
Showing 11 to 20 of 31 entries
Summary

The mouse and human DIO3OS and DIO3 (MIM 601038) genes overlap and are transcribed in opposite directions. The mouse Dio3 gene is imprinted from the paternal allele during fetal development, suggesting that DIO3OS is a noncoding gene that may have a role in maintaining monoallelic expression of DIO3 (Hernandez et al., 2004 [PubMed 14962667]).[supplied by OMIM, Mar 2008]

Forensic Context

A study in mice demonstrated that the DIO3OS was identified as a significantly downregulated RNA marker (0.512-fold reduction) in lung tissue following hypothermia-induced death, classifying it as a candidate forensic biomarker for this condition [Takamiya et al. DOI:10.1016/J.Legalmed.2020.101789].