Basic Information

Symbol
DIO3OS
RNA class
lncRNA
Alias
DIO3-AS1 Dio3as ENSG00000251028 ENSG00000258498 ENSG00000258498.1 ENSG00000258498.2 ENSG00000258498.6 ENSG00000258498.7 ENSG00000258498.8 NCRNA00041 OTTHUMG00000171682.1
Location (GRCh38)
14:101552221-101560431
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
DIO3OS:28 GCUGGGCGCACCCGUCCCGUUCGUCCCCGGACGUUGCUCUCUACCCCGG… 1085 nt 0.6369
DIO3OS:29 GCUGGGCGCACCCGUCCCGUUCGUCCCCGGACGUUGCUCUCUACCCCGG… 1898 nt 0.6338
DIO3OS:3 GCCCAGCGCAGCCCCGGCCGCUGGGCGCACCCGUCCCGUUCGUCCCCGG… 3108 nt 0.6252
DIO3OS:30 GCUGGGCGCACCCGUCCCGUUCGUCCCCGGACGUUGCUCUCUACCCCGG… 855 nt 0.6152
DIO3OS:31 GCUGGGCGCACCCGUCCCGUUCGUCCCCGGACGUUGCUCUCUACCCCGG… 701 nt 0.6148
DIO3OS:4 CAGCCCCGGCCGCUGGGCGCACCCGUCCCGUUCGUCCCCGGACGUUGCU… 866 nt 0.6189
DIO3OS:5 CAGCCCCGGCCGCUGGGCGCACCCGUCCCGUUCGUCCCCGGACGUUGCU… 686 nt 0.5977
DIO3OS:6 CAGCCCCGGCCGCUGGGCGCACCCGUCCCGUUCGUCCCCGGACGUUGCU… 712 nt 0.6194
DIO3OS:7 CAGCCCCGGCCGCUGGGCGCACCCGUCCCGUUCGUCCCCGGACGUUGCU… 952 nt 0.5735
DIO3OS:8 GCUGGGCGCACCCGUCCCGUUCGUCCCCGGACGUUGCUCUCUACCCCGG… 579 nt 0.7064
Showing 21 to 30 of 31 entries
Summary

The mouse and human DIO3OS and DIO3 (MIM 601038) genes overlap and are transcribed in opposite directions. The mouse Dio3 gene is imprinted from the paternal allele during fetal development, suggesting that DIO3OS is a noncoding gene that may have a role in maintaining monoallelic expression of DIO3 (Hernandez et al., 2004 [PubMed 14962667]).[supplied by OMIM, Mar 2008]

Forensic Context

A study in mice demonstrated that the DIO3OS was identified as a significantly downregulated RNA marker (0.512-fold reduction) in lung tissue following hypothermia-induced death, classifying it as a candidate forensic biomarker for this condition [Takamiya et al. DOI:10.1016/J.Legalmed.2020.101789].