Basic Information

Symbol
DLEU2
RNA class
lncRNA
Alias
ENSG00000231607 ENSG00000231607.10 ENSG00000231607.2 ENSG00000231607.4 ENSG00000231607.8 ENSG00000231607.9 LEU2 LINC00022 MIR15AHG NCRNA00022 OTTHUMG00000016927.1 TRIM13OS
Location (GRCh38)
13:49912706-50125720
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
DLEU2:1 GGGGAGCAGAAGGCCGCGGGCGGGCGGCUGGCGCGCUGUGUACUUAGGU… 1267 nt 0.4696
DLEU2:10 CGCCAUUUUCGAGUGAUGCCUGAUCUCAUCAAUCUAGCGGGAGAGACAG… 698 nt 0.3496
DLEU2:11 GCCAUUUUCGAGUGAUGCCUGAUCUCAUCAAUCUAGCGGGAGAGACAGG… 1294 nt 0.3238
DLEU2:12 GAUGCCUGAUCUCAUCAAUCUAGCGGGAGAGACAGGAUAACCUGUCCGA… 2090 nt 0.3478
DLEU2:13 GAUGCCUGAUCUCAUCAAUCUAGCGGGAGAGACAGGAUAACCUGUCCGA… 1251 nt 0.3213
DLEU2:14 GAUGCCUGAUCUCAUCAAUCUAGCGGGAGAGACAGGAUAACCUGUCCGA… 1116 nt 0.3566
DLEU2:15 GAUGCCUGAUCUCAUCAAUCUAGCGGGAGAGACAGGAUAACCUGUCCGA… 791 nt 0.3338
DLEU2:16 GAUGCCUGAUCUCAUCAAUCUAGCGGGAGAGACAGGAUAACCUGUCCGA… 1739 nt 0.3094
DLEU2:17 GAUGCCUGAUCUCAUCAAUCUAGCGGGAGAGACAGGAUAACCUGUCCGA… 1657 nt 0.3120
DLEU2:18 CUGAUCUCAUCAAUCUAGCGGGAGAGACAGGAUAACCUGUCCGAGAGUA… 692 nt 0.3266
Showing 1 to 10 of 48 entries
Summary

This locus represents a microRNA host gene and also produces long alternatively spliced non-coding RNAs. This genome region was observed to be deleted or epigenetically suppressed in leukemia, and was implicated as a negative regulator of cell proliferation. However, an alternative transcript produced at this locus was also found to promote progression through the cell cycle via angiotensin I converting enzyme 2 and cyclin D1. [provided by RefSeq, Dec 2017]

Forensic Context

A study in human aortic endothelial cells demonstrated that the DLEU2 (DLEU2) was identified as a radiation-responsive long non-coding RNA, where its expression was commonly altered across all tested X-ray doses (1-10 Gy) at 24 hours post-irradiation and could differentiate unirradiated (0 Gy) samples from dosed samples, supporting its role as a potential biomarker for biodosimetry applications [Chopra et al. DOI:10.1038/s41598-022-24051-6].