Basic Information

Symbol
DLEU2
RNA class
lncRNA
Alias
ENSG00000231607 ENSG00000231607.10 ENSG00000231607.2 ENSG00000231607.4 ENSG00000231607.8 ENSG00000231607.9 LEU2 LINC00022 MIR15AHG NCRNA00022 OTTHUMG00000016927.1 TRIM13OS
Location (GRCh38)
13:49912706-50125720
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
DLEU2:28 CCGGGUUAAAGCGAUUCUCCAGCUUCAGUCUCCCAAGUAGCUGGGAUUA… 409 nt 0.5061
DLEU2:29 AUUAUGUGGGGCCAGGAUAUCAUGGCUGUUAAAUGACUGCCCAUGUGAC… 1711 nt 0.4436
DLEU2:3 GGAGCUUUGCUGAAACUGCACAAAAAAUCGAGCCGGGGGGUUCCCUGGU… 3068 nt 0.4684
DLEU2:30 GAAGGACUGGUGACUCACCCUAGCAUUUUCUCUUUGCACAGAAACAGAU… 352 nt 0.5000
DLEU2:31 GGAGCUUUGCUGAAACUGCACAAAAAAUCGAGCCGGGGGGUUCCCUGGU… 5056 nt 0.4846
DLEU2:32 GGAGCUUUGCUGAAACUGCACAAAAAAUCGAGCCGGGGGGUUCCCUGGU… 6976 nt 0.3978
DLEU2:33 GGAGCUUUGCUGAAACUGCACAAAAAAUCGAGCCGGGGGGUUCCCUGGU… 1088 nt 0.4430
DLEU2:34 GGAGCUUUGCUGAAACUGCACAAAAAAUCGAGCCGGGGGGUUCCCUGGU… 1755 nt 0.5282
DLEU2:35 GGAGCUUUGCUGAAACUGCACAAAAAAUCGAGCCGGGGGGUUCCCUGGU… 1492 nt 0.3968
DLEU2:36 GCCAUUUUCGAGUGAUGCCUGAUCUCAUCAAUCUAGCGGGAGAGACAGG… 1873 nt 0.5392
Showing 21 to 30 of 48 entries
Summary

This locus represents a microRNA host gene and also produces long alternatively spliced non-coding RNAs. This genome region was observed to be deleted or epigenetically suppressed in leukemia, and was implicated as a negative regulator of cell proliferation. However, an alternative transcript produced at this locus was also found to promote progression through the cell cycle via angiotensin I converting enzyme 2 and cyclin D1. [provided by RefSeq, Dec 2017]

Forensic Context

A study in human aortic endothelial cells demonstrated that the DLEU2 (DLEU2) was identified as a radiation-responsive long non-coding RNA, where its expression was commonly altered across all tested X-ray doses (1-10 Gy) at 24 hours post-irradiation and could differentiate unirradiated (0 Gy) samples from dosed samples, supporting its role as a potential biomarker for biodosimetry applications [Chopra et al. DOI:10.1038/s41598-022-24051-6].