Forensic Context

A study in humans demonstrated that the lnc-MRPL37-1 is a long non-coding RNA whose expression in peripheral blood is significantly negatively correlated with chronological age (ρ = -0.4583), decreasing with advancing age [Chen et al. DOI:10.1016/J.Fsigen.2025.103419]. This lncRNA was identified as one of 20 candidate biomarkers used to construct forensic age prediction models via machine learning, with the best-performing XGBoost model achieving a mean absolute error of 8.04 years in the test cohort and similar performance in external validation datasets.