Basic Information

Symbol
lnc-MSX1-2
RNA class
lncRNA
Alias
STX18-AS1 LOC101928279 XLOC_003433 linc-MSX1-1
Location (GRCh38)
4:4761760-4787374
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
lnc-MSX1-2:1 AAAUUUUGCAUUCGGCUGCCUUAGCACUCUGCGUCCUCGCACCGACCCU… 2341 nt 0.4652
lnc-MSX1-2:2 AAUUGCAGACUGGCCUUUACAAGGGAAAAACCCAGGCCCUGCCCUAAAU… 2386 nt 0.4665
lnc-MSX1-2:3 GCAUUCGGCUGCCUUAGCACUCUGCGUCCUCGCACCGACCCUGGGGUCC… 435 nt 0.5356
lnc-MSX1-2:4 GCAUUCGGCUGCCUUAGCACUCUGCGUCCUCGCACCGACCCUGGGGUCC… 475 nt 0.5032
lnc-MSX1-2:5 GCAUUCGGCUGCCUUAGCACUCUGCGUCCUCGCACCGACCCUGGGGUCC… 18797 nt 0.4666
Summary

No relevant information is available at the moment.

Forensic Context

A study in human postmortem midbrain specimens demonstrated that the lnc-MSX1-2 was significantly down-regulated (-1.35-fold) in chronic cocaine abusers compared to well-matched controls, as identified via a custom lncRNA microarray [Bannon et al. DOI:10.1111/jnc.13255]. This antisense lncRNA was part of a validated profile of 32 dysregulated lncRNAs, implicating it in the cellular responses of human dopamine neurons to chronic cocaine abuse.