Forensic Context

A study in humans demonstrated that the lnc-NAV1-5 is frequently implicated in autopsy-negative sudden unexplained death, where molecular autopsy via next-generation sequencing identifies pathogenic variants associated with channelopathies like Brugada and Long QT syndromes [Sacco et al. DOI:10.3390/ijms27020670]. In arrhythmogenic cardiomyopathy models using human and mouse samples, impaired localization and function of the lnc-NAV1-5 were noted as potentially explaining phenotypic complexity [Chen et al. DOI:10.1161/CIRCRESAHA.114.302810].