Forensic Context

A study in mice and rats demonstrated that the lnc-PCK1-5 is downregulated following traumatic brain injury, where its decrease promotes proliferation and inhibits apoptosis by binding to miR-195 and upregulating NLRX1 [Li et al. DOI:10.1016/j.neuint.2023.105643]. In the context of radiation response, research in human laryngeal cancer cells indicates that knockdown of the lnc-PCK1-5 results in radioresistance by targeting the NF-κB pathway [May et al. DOI:10.1016/j.trsl.2021.02.005].