Basic Information
Symbol
lnc-ZFAT-1
RNA class
lncRNA
Alias
AC083843.1
AC083843.2
AC083843.3
ENSG00000259820.1
OTTHUMG00000164324.1
Location (GRCh38)
8:134781085-134832309
Forensic tag(s)
Drug abuse diagnoses
External database
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| lnc-ZFAT-1:1 | AUAUGUUCUGAAAUUAAACUUGAACUUUUUUCUGUGAAUUUUGAAGAUU… | 6253 nt | 0.3621 |
| lnc-ZFAT-1:2 | AUCGAGCGUUUAUUGUGAUCAUGGCCAAAAAUAAAAUAAUUCUUUGACU… | 5608 nt | 0.3538 |
| lnc-ZFAT-1:3 | GCUCUCCCUCAGACACACUGGAGGGAAAGGUCAAACUAAAGGCGAGGGA… | 27380 nt | 0.3748 |
| lnc-ZFAT-1:4 | GCUCUCCCUCAGACACACUGGAGGGAAAGGUCAAACUAAAGGCGAGGGA… | 3186 nt | 0.4448 |
| lnc-ZFAT-1:5 | GCUCUCCCUCAGACACACUGGAGGGAAAGGUCAAACUAAAGGCGAGGGA… | 1426 nt | 0.5049 |
| lnc-ZFAT-1:6 | GCUCUCCCUCAGACACACUGGAGGGAAAGGUCAAACUAAAGGCGAGGGA… | 25828 nt | 0.3632 |
| lnc-ZFAT-1:7 | GCUCUCCCUCAGACACACUGGAGGGAAAGGUCAAACUAAAGGCGAGGGA… | 1851 nt | 0.4603 |
| lnc-ZFAT-1:8 | CCGGCUAUUCACAGACAUCCUCUUGAUAUAAUUCUGUCCCGGAGUGGAG… | 23792 nt | 0.3588 |
Summary
No relevant information is available at the moment.
Forensic Context
A study in human postmortem midbrain specimens from chronic cocaine abusers identified the lnc-ZFAT-1 as a dysregulated long noncoding RNA, showing a 1.33-fold up-regulation in cocaine abusers compared to matched controls [Bannon et al. DOI:10.1111/jnc.13255]. This intergenic lncRNA is adjacent to MIR30B and MIR30D on the same strand, and its differential expression was part of a validated profile of 32 lncRNAs implicated in the cellular responses of human dopamine neurons to chronic cocaine abuse.