Basic Information

Symbol
NEAT1
RNA class
lncRNA
Alias
ENSG00000245532 ENSG00000245532.2 ENSG00000245532.4 ENSG00000245532.5 ENSG00000245532.6 ENSG00000245532.7 ENSG00000245532.8 LINC00084 MENepsilon/beta OTTHUMG00000166321.3 TncRNA VINC
Location (GRCh38)
11:65416582-65450093
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses Postmortem interval inference Other applications
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
NEAT1:2 CUGACCUGGCUUCAGAACAAGAUGUGGGGCUCCAGGCACCCGGGAGACC… 1913 nt 0.5363
NEAT1:20 AGUGAGCAGCACUGCCCGCCCAGGCAACCUGGAACCAGGGUCGUGCCCC… 20864 nt 0.4514
NEAT1:21 GACAGUGCAGUUUCCAGACCCAGGCCCUGAGCUGAGGGGCCUCAGGGCU… 26588 nt 0.4672
NEAT1:22 GCCUCCCAAAUGUCACCUUGAGCGCUGUCCGCGAUCCCAAAAAGCACUG… 14927 nt 0.4364
NEAT1:23 GGAGUUAGCGACAGGGAGGGAUGCGCGCCUGGGUGUAGUUGUGGGGGAG… 1474 nt 0.5821
NEAT1:24 GGAGUUAGCGACAGGGAGGGAUGCGCGCCUGGGUGUAGUUGUGGGGGAG… 1721 nt 0.5404
NEAT1:25 GGAGUUAGCGACAGGGAGGGAUGCGCGCCUGGGUGUAGUUGUGGGGGAG… 1952 nt 0.5446
NEAT1:26 GGAGUUAGCGACAGGGAGGGAUGCGCGCCUGGGUGUAGUUGUGGGGGAG… 6847 nt 0.4611
NEAT1:27 GGAGUUAGCGACAGGGAGGGAUGCGCGCCUGGGUGUAGUUGUGGGGGAG… 22743 nt 0.4405
NEAT1:28 GGAGUUAGCGACAGGGAGGGAUGCGCGCCUGGGUGUAGUUGUGGGGGAG… 22525 nt 0.4404
Showing 11 to 20 of 35 entries
Summary

This gene produces a long non-coding RNA (lncRNA) transcribed from the multiple endocrine neoplasia locus. This lncRNA is retained in the nucleus where it forms the core structural component of the paraspeckle sub-organelles. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer progression. [provided by RefSeq, Mar 2015]

Forensic Context

A study in human postmortem midbrain specimens from chronic cocaine abusers identified a profile of 32 dysregulated long noncoding RNAs (lncRNAs) using a custom microarray, with differential expression validated by qPCR and in situ hybridization for a subset, including dopamine neuron-specific localization for LINC00162 and TRAF3IP2-AS1 [Bannon et al. DOI:10.1111/jnc.13255]. A review notes that the lncRNA NEAT1 is upregulated in the peripheral blood of Parkinson's disease patients and sponges miR-124 to accelerate pathology, highlighting its role as a biomarker in neurological disorders [Das et al. DOI:10.1080/21655979.2021.2003667]. A review of forensic proteomics literature identifies the NEAT1 as a protein marker for post-mortem interval (PMI) estimation in early PMI skeletal muscle, where it shows degradation products post-mortem [Alex et al. DOI:10.1016/j.scijus.2025.101320].