Basic Information

Symbol
NEAT1
RNA class
lncRNA
Alias
ENSG00000245532 ENSG00000245532.2 ENSG00000245532.4 ENSG00000245532.5 ENSG00000245532.6 ENSG00000245532.7 ENSG00000245532.8 LINC00084 MENepsilon/beta OTTHUMG00000166321.3 TncRNA VINC
Location (GRCh38)
11:65416582-65450093
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses Postmortem interval inference Other applications
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
NEAT1:29 GGAGUUAGCGACAGGGAGGGAUGCGCGCCUGGGUGUAGUUGUGGGGGAG… 22170 nt 0.4373
NEAT1:3 GCAAAAGUUGUGGCAAGUCCAGCCGGAGUUAGCGACAGGGAGGGAUGCG… 1745 nt 0.5404
NEAT1:30 GCAAAAGUUGUGGCAAGUCCAGCCGGAGUUAGCGACAGGGAGGGAUGCG… 3441 nt 0.4760
NEAT1:31 AGUUAGCGACAGGGAGGGAUGCGCGCCUGGGUGUAGUUGUGGGGGAGGA… 3524 nt 0.4844
NEAT1:32 AGCGACAGGGAGGGAUGCGCGCCUGGGUGUAGUUGUGGGGGAGGAAGUG… 1053 nt 0.5745
NEAT1:33 AUAGCUGAGCGAGCCCGGACCAAGGGCUGUGAACCCGCCUGGGGAUGAG… 2994 nt 0.4489
NEAT1:34 UGUGUGGAAGGAGGAAGGCAGGGAGAGGUAGAAGGGGUGGAGGAGUCAG… 3300 nt 0.4664
NEAT1:35 GCGGCACCUAGCAUGUUUGACAGGCGGGGACUGCGAGGCACGCUGCUCG… 1145 nt 0.4961
NEAT1:36 UGGAAGUCUUAGAAAAGCCUUGUAAAUGCCUAUAUUGUGGGCUUUUAAC… 512 nt 0.3652
NEAT1:4 GCAAAAGUUGUGGCAAGUCCAGCCGGAGUUAGCGACAGGGAGGGAUGCG… 1811 nt 0.5334
Showing 21 to 30 of 35 entries
Summary

This gene produces a long non-coding RNA (lncRNA) transcribed from the multiple endocrine neoplasia locus. This lncRNA is retained in the nucleus where it forms the core structural component of the paraspeckle sub-organelles. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer progression. [provided by RefSeq, Mar 2015]

Forensic Context

A study in human postmortem midbrain specimens from chronic cocaine abusers identified a profile of 32 dysregulated long noncoding RNAs (lncRNAs) using a custom microarray, with differential expression validated by qPCR and in situ hybridization for a subset, including dopamine neuron-specific localization for LINC00162 and TRAF3IP2-AS1 [Bannon et al. DOI:10.1111/jnc.13255]. A review notes that the lncRNA NEAT1 is upregulated in the peripheral blood of Parkinson's disease patients and sponges miR-124 to accelerate pathology, highlighting its role as a biomarker in neurological disorders [Das et al. DOI:10.1080/21655979.2021.2003667]. A review of forensic proteomics literature identifies the NEAT1 as a protein marker for post-mortem interval (PMI) estimation in early PMI skeletal muscle, where it shows degradation products post-mortem [Alex et al. DOI:10.1016/j.scijus.2025.101320].