Basic Information

Symbol
OIP5-AS1
RNA class
lncRNA
Alias
AC012652.1 ENSG00000247556 ENSG00000247556.2 ENSG00000247556.6 OTTHUMG00000172547.2 XLOC_011226 cyrano linc-NUSAP1 linc-OIP5
Location (GRCh38)
15:41283963-41508868
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden death from respiratory system disease
External database
HGNC NCBI Ensembl LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
OIP5-AS1:4 AGGGUUGGCCACCUUGAGAAGCUGCGAAGAUGGCGGAGUAAGGCGUGCC… 1269 nt 0.4815
OIP5-AS1:5 AGGGUUGGCCACCUUGAGAAGCUGCGAAGAUGGCGGAGUAAGGCGUGCC… 676 nt 0.4260
OIP5-AS1:6 UUGAGAAGCUGCGAAGAUGGCGGAGUAAGGCGUGCCGCUGCAAACUGGC… 1893 nt 0.4337
OIP5-AS1:7 UUGAGAAGCUGCGAAGAUGGCGGAGUAAGGCGUGCCGCUGCAAACUGGC… 1894 nt 0.4335
OIP5-AS1:8 UGAGAAGCUGCGAAGAUGGCGGAGUAAGGCGUGCCGCUGCAAACUGGCC… 249 nt 0.5663
OIP5-AS1:9 GAGAAGCUGCGAAGAUGGCGGAGUAAGGCGUGCCGCUGCAAACUGGCCU… 4265 nt 0.4007
Showing 31 to 36 of 36 entries
Summary

This is a conserved gene that produces a long non-coding RNA that maintains cell proliferation in embryonic stem cells. This RNA can bind to and negatively regulate the activity of multiple cellular RNAs and microRNAs, including cyclin G associated kinase and ELAV like RNA binding protein 1. [provided by RefSeq, Dec 2017]

Forensic Context

A study in humans identified the OIP5-AS1 as a hub long non-coding RNA within a constructed ceRNA network for sepsis, having the highest degree distribution and being part of regulator pairs used for drug prediction [Wang et al. DOI:10.1016/j.heliyon.2024.e27379]. In a separate investigation of sepsis-induced acute respiratory distress syndrome, the OIP5-AS1 was noted as a potential regulator that modulates GPR65 expression through specific miRNAs and worsens LPS-induced acute lung injury/ARDS [Liu et al. DOI:10.3389/fimmu.2025.1528769].