Basic Information

Symbol
PVT1
RNA class
lncRNA
Alias
ENSG00000249859 ENSG00000249859.2 ENSG00000249859.3 ENSG00000249859.7 ENSG00000249859.8 ENSG00000249859.9 LINC00079 NCRNA00079 OTTHUMG00000164871.1 XLOC_006922 XLOC_006924 XLOC_006925 linc-EFR3A-4 linc-EFR3A-5 linc-EFR3A-7 onco-lncRNA-100
Location (GRCh38)
8:127794523-128188211
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
PVT1:64 GAUGCCCCUCAAGAUGGCUGUGCCUGUCAGCUGCAUGGAGCUUCGUUCA… 471 nt 0.4989
PVT1:65 GAUGCCCCUCAAGAUGGCUGUGCCUGUCAGCUGCAUGGAGCUUCGUUCA… 452 nt 0.5332
PVT1:66 GAUGCCCCUCAAGAUGGCUGUGCCUGUCAGCUGCAUGGAGCUUCGUUCA… 609 nt 0.5041
PVT1:67 GAUGCCCCUCAAGAUGGCUGUGCCUGUCAGCUGCAUGGAGCUUCGUUCA… 1706 nt 0.5229
PVT1:68 GAUGCCCCUCAAGAUGGCUGUGCCUGUCAGCUGCAUGGAGCUUCGUUCA… 598 nt 0.4799
PVT1:69 AGAUUCCUGGGAACACCACCAUGGAGGGCCUGGCCUUUGGCGGUGGACA… 7191 nt 0.4867
PVT1:7 GCCGAGCACAUGGGCCCGCGGGCCGGGCGGGCUCGGGGCGGCCGGGACG… 2164 nt 0.4737
PVT1:70 GACAUUGAGUGCCUGGAGCCCUCCCUAGCUCUCCAGCUGGAACCUUCCU… 2371 nt 0.4757
PVT1:71 GACAUUGAGUGCCUGGAGCCCUCCCUAGCUCUCCAGCUGGAACCUUCCU… 1262 nt 0.4826
PVT1:72 GACAUUGAGUGCCUGGAGCCCUCCCUAGCUCUCCAGCUGGAACCUUCCU… 575 nt 0.4713
Showing 61 to 70 of 83 entries
Summary

This gene represents a long non-coding RNA locus that has been identified as a candidate oncogene. Increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Allelic variants of this gene are also associated with end-stage renal disease attributed to type 1 diabetes. Consistent with its association with various types of cancer, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis. [provided by RefSeq, Sep 2015]

Forensic Context

A study in mice demonstrated that the PVT1 was upregulated in response to intermediate- to high-dose whole-body X-ray irradiation at 16- and 24-hour time points in blood, identifying it as a p53-associated lncRNA for radiation biodosimetry [Aryankalayil et al. DOI:10.1667/RR14891.1]. In a separate investigation of myocardial ischemia-reperfusion injury in mice, the PVT1 was significantly upregulated in cardiac tissues and hypoxic cardiomyocytes, classifying it among the top differentially expressed lncRNAs in this pathological context [Luo et al. DOI:10.3389/fcell.2021.615950].