Basic Information

Symbol
PVT1
RNA class
lncRNA
Alias
ENSG00000249859 ENSG00000249859.2 ENSG00000249859.3 ENSG00000249859.7 ENSG00000249859.8 ENSG00000249859.9 LINC00079 NCRNA00079 OTTHUMG00000164871.1 XLOC_006922 XLOC_006924 XLOC_006925 linc-EFR3A-4 linc-EFR3A-5 linc-EFR3A-7 onco-lncRNA-100
Location (GRCh38)
8:127794523-128188211
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
PVT1:73 GACAUUGAGUGCCUGGAGCCCUCCCUAGCUCUCCAGCUGGAACCUUCCU… 999 nt 0.4334
PVT1:74 GACAUUGAGUGCCUGGAGCCCUCCCUAGCUCUCCAGCUGGAACCUUCCU… 893 nt 0.4927
PVT1:75 AUAUAGAGUCUCACUCUGUGGUCCAGGCUGAAGUACAGUGGCAUGAUCC… 13144 nt 0.4411
PVT1:76 AUAUAGAGUCUCACUCUGUGGUCCAGGCUGAAGUACAGUGGCAUGAUCC… 666 nt 0.4985
PVT1:77 AUAUAGAGUCUCACUCUGUGGUCCAGGCUGAAGUACAGUGGCAUGAUCC… 1113 nt 0.4852
PVT1:78 AUAUAGAGUCUCACUCUGUGGUCCAGGCUGAAGUACAGUGGCAUGAUCC… 970 nt 0.5082
PVT1:79 AUAUAGAGUCUCACUCUGUGGUCCAGGCUGAAGUACAGUGGCAUGAUCC… 19273 nt 0.4721
PVT1:8 GCCGAGCACAUGGGCCCGCGGGCCGGGCGGGCUCGGGGCGGCCGGGACG… 1221 nt 0.5102
PVT1:80 CAGAGUUUCACUCUUGUUGCCUAGGGUGGAGUACAAUGGCGUGAUCUCA… 1117 nt 0.4440
PVT1:81 GAGAGGCAGGCGGGCCCUAGCUGCAGCGUCAAGGUCUGGGGAUUCUGUG… 569 nt 0.5712
Showing 71 to 80 of 83 entries
Summary

This gene represents a long non-coding RNA locus that has been identified as a candidate oncogene. Increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Allelic variants of this gene are also associated with end-stage renal disease attributed to type 1 diabetes. Consistent with its association with various types of cancer, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis. [provided by RefSeq, Sep 2015]

Forensic Context

A study in mice demonstrated that the PVT1 was upregulated in response to intermediate- to high-dose whole-body X-ray irradiation at 16- and 24-hour time points in blood, identifying it as a p53-associated lncRNA for radiation biodosimetry [Aryankalayil et al. DOI:10.1667/RR14891.1]. In a separate investigation of myocardial ischemia-reperfusion injury in mice, the PVT1 was significantly upregulated in cardiac tissues and hypoxic cardiomyocytes, classifying it among the top differentially expressed lncRNAs in this pathological context [Luo et al. DOI:10.3389/fcell.2021.615950].