Basic Information
Symbol
SMAD5-AS1
RNA class
lncRNA
Alias
DAMS
ENSG00000164621
ENSG00000164621.5
OTTHUMG00000163216.1
Location (GRCh38)
5:136129499-136134890
Forensic tag(s)
Drug abuse diagnoses
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| SMAD5-AS1:1 | UGAUCUGAAAGGAAUGGAAGCACAAAAUGAUGAAUAAGGUAUUUUUAAC… | 1816 nt | 0.4273 |
| SMAD5-AS1:2 | UGAUCUGAAAGGAAUGGAAGCACAAAAUGAUGAAUAAGGUAUUUUUAAC… | 1809 nt | 0.4279 |
| SMAD5-AS1:3 | GGUGAAGGCAAAAAGACGCUGCUUUGGCAUUCUCUUUGCAGCACAGAGA… | 579 nt | 0.4870 |
| SMAD5-AS1:4 | UGAUCUGAAAGGAAUGGAAGCACAAAAUGAUGAAUAAGGUAUUUUUAAC… | 1810 nt | 0.4276 |
Summary
Enables miRNA inhibitor activity via base-pairing. Involved in lncRNA-mediated post-transcriptional gene silencing and positive regulation of BMP signaling pathway. [provided by Alliance of Genome Resources, Jul 2025]
Forensic Context
A study in human postmortem nucleus accumbens tissue identified that the SMAD5-AS1 was represented on Affymetrix U133 arrays and was expressed in most but not all subjects, with a trend towards a group-wise difference between heroin abusers and drug-free controls [Michelhaugh et al. DOI:10.1111/J.1471-4159.2010.07126.X].