Basic Information

Symbol
SNHG1
RNA class
lncRNA
Alias
ENSG00000255717 ENSG00000255717.1 ENSG00000255717.2 ENSG00000255717.6 LINC00057 NCRNA00057 OTTHUMG00000167743.1 UHG lncRNA16
Location (GRCh38)
11:62851874-62856011
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation Other applications
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
SNHG1:1 CUCUACCCACAACUCCCCGGGGUCGCAUGCGGUCAACGUAUGCGCGUGC… 3284 nt 0.4339
SNHG1:10 GUGGUAAGUGGCUUCGUGGUCUUUAUAGCUGUUACUCUUUUGUACUUUG… 1487 nt 0.4539
SNHG1:11 UCUUUUAUUUUCUUUUGAGCGAUUGUGCGAACAUAGCAUAGCACGCACU… 996 nt 0.4538
SNHG1:12 UUCUGUGUUGUAGCUGCCUGGCCAGGGCGACUGGCGGAUAAGGUCUUGU… 870 nt 0.4632
SNHG1:13 GCUGCCUGGCCAGGGCGACUGGCGGAUAAGGUCUUGUGCGUGGCCUCGA… 1374 nt 0.4592
SNHG1:14 CUUAUUGGGCUCCUGUCUGCAGGAUUUACGCGCACGUUGGAACCGAAGA… 748 nt 0.4492
SNHG1:15 CUUAUUGGGCUCCUGUCUGCAGGAUUUACGCGCACGUUGGAACCGAAGA… 646 nt 0.4118
SNHG1:16 CUUAUUGGGCUCCUGUCUGCAGGAUUUACGCGCACGUUGGAACCGAAGA… 588 nt 0.4660
SNHG1:17 CUUAUUGGGCUCCUGUCUGCAGGAUUUACGCGCACGUUGGAACCGAAGA… 594 nt 0.4343
SNHG1:18 CUUAUUGGGCUCCUGUCUGCAGGAUUUACGCGCACGUUGGAACCGAAGA… 754 nt 0.4509
Showing 1 to 10 of 64 entries
Summary

This locus represents a small nucleolar RNA host gene that produces multiple alternatively spliced long non-coding RNAs. This gene is upregulated in cancers and is thought to act as promoter of cell proliferation. This transcript negatively regulates tumor suppressor genes such as tumor protein p53. Expression of this locus may be a marker of tumor progression. [provided by RefSeq, Dec 2017]

Forensic Context

A study in humans demonstrated that the SNHG1 was upregulated in subcutaneous adipose tissue during short-term weight loss [Bollepalli et al. DOI:10.1038/ijo.2017.245]. A review of non-coding RNAs in neurological diseases reported that the SNHG1 is detected in brain tissue of Parkinson's disease patients and is also investigated as a therapeutic target for such disorders [Das et al. DOI:10.1080/21655979.2021.2003667].