Basic Information

Symbol
SNHG1
RNA class
lncRNA
Alias
ENSG00000255717 ENSG00000255717.1 ENSG00000255717.2 ENSG00000255717.6 LINC00057 NCRNA00057 OTTHUMG00000167743.1 UHG lncRNA16
Location (GRCh38)
11:62851874-62856011
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation Other applications
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
SNHG1:28 GAAGGGUGUUAUUUUUUCAGAUGUUCAGCCCACAAGAGCUUACUGGUGA… 1071 nt 0.4351
SNHG1:29 GAAGGGUGUUAUUUUUUCAGAUGUUCAGCCCACAAGAGCUUACUGGUGA… 955 nt 0.4419
SNHG1:3 GUUCUCAUUUUUCUACUGCUCGUGGAUUUACGCGCACGUUGGAACCGAA… 1118 nt 0.4392
SNHG1:30 GACCCAUCUUUAUGCAAAGCCAGCGUUACAGUAAUGUUCCAGCAUCUCA… 240 nt 0.4542
SNHG1:31 CACUGAUCUGCCCAGGGUCAGACGAAUGCUUGUCAGUUGUAGCUUUCCA… 625 nt 0.4336
SNHG1:32 UGACUUGCUGUUGAGACUCUGAAAUCUGAUUUUCUGAGAAUGAUGGGUG… 849 nt 0.4417
SNHG1:33 CUCAUUUUUCUACUGCUCGUGGUAAGUGGCUUCGUGGUCUUUAUAGCUG… 2740 nt 0.4299
SNHG1:34 CUCAUUUUUCUACUGCUCGUGGUAAGUGGCUUCGUGGUCUUUAUAGCUG… 2463 nt 0.4373
SNHG1:35 CUCAUUUUUCUACUGCUCGUGGAUUUACGCGCACGUUGGAACCGAAGAG… 1066 nt 0.4371
SNHG1:36 CUCAUUUUUCUACUGCUCGUGGAUUUACGCGCACGUUGGAACCGAAGAG… 633 nt 0.4408
Showing 21 to 30 of 64 entries
Summary

This locus represents a small nucleolar RNA host gene that produces multiple alternatively spliced long non-coding RNAs. This gene is upregulated in cancers and is thought to act as promoter of cell proliferation. This transcript negatively regulates tumor suppressor genes such as tumor protein p53. Expression of this locus may be a marker of tumor progression. [provided by RefSeq, Dec 2017]

Forensic Context

A study in humans demonstrated that the SNHG1 was upregulated in subcutaneous adipose tissue during short-term weight loss [Bollepalli et al. DOI:10.1038/ijo.2017.245]. A review of non-coding RNAs in neurological diseases reported that the SNHG1 is detected in brain tissue of Parkinson's disease patients and is also investigated as a therapeutic target for such disorders [Das et al. DOI:10.1080/21655979.2021.2003667].