Basic Information

Symbol
SNHG1
RNA class
lncRNA
Alias
ENSG00000255717 ENSG00000255717.1 ENSG00000255717.2 ENSG00000255717.6 LINC00057 NCRNA00057 OTTHUMG00000167743.1 UHG lncRNA16
Location (GRCh38)
11:62851874-62856011
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation Other applications
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
SNHG1:46 UCUGCAGGAUUUACGCGCACGUUGGAACCGAAGAGAGCUCUGUUGUUGC… 573 nt 0.4642
SNHG1:47 UCUGCAGGAUUUACGCGCACGUUGGAACCGAAGAGAGCUCUGUUGUUGC… 1308 nt 0.4358
SNHG1:48 UCUGCAGGAUUUACGCGCACGUUGGAACCGAAGAGAGCUCUGUUGUUGC… 1051 nt 0.4415
SNHG1:49 UCUGCAGGAUUUACGCGCACGUUGGAACCGAAGAGAGCUCUGUUGUUGC… 1192 nt 0.4413
SNHG1:5 UUUUUCUACUGCUCGUGGAUUUACGCGCACGUUGGAACCGAAGAGAGCU… 629 nt 0.4404
SNHG1:50 UCUGCAGGAUUUACGCGCACGUUGGAACCGAAGAGAGCUCUGUUGUUGC… 739 nt 0.4493
SNHG1:51 UCUGCAGGAUUUACGCGCACGUUGGAACCGAAGAGAGCUCUGUUGUUGC… 733 nt 0.4475
SNHG1:52 UCUGCAGGAUUUACGCGCACGUUGGAACCGAAGAGAGCUCUGUUGUUGC… 353 nt 0.4618
SNHG1:53 UCUGCAGGAUUUACGCGCACGUUGGAACCGAAGAGAGCUCUGUUGUUGC… 623 nt 0.4366
SNHG1:54 UCUGCAGGAUUUACGCGCACGUUGGAACCGAAGAGAGCUCUGUUGUUGC… 621 nt 0.4509
Showing 41 to 50 of 64 entries
Summary

This locus represents a small nucleolar RNA host gene that produces multiple alternatively spliced long non-coding RNAs. This gene is upregulated in cancers and is thought to act as promoter of cell proliferation. This transcript negatively regulates tumor suppressor genes such as tumor protein p53. Expression of this locus may be a marker of tumor progression. [provided by RefSeq, Dec 2017]

Forensic Context

A study in humans demonstrated that the SNHG1 was upregulated in subcutaneous adipose tissue during short-term weight loss [Bollepalli et al. DOI:10.1038/ijo.2017.245]. A review of non-coding RNAs in neurological diseases reported that the SNHG1 is detected in brain tissue of Parkinson's disease patients and is also investigated as a therapeutic target for such disorders [Das et al. DOI:10.1080/21655979.2021.2003667].