Basic Information

Symbol
SNHG1
RNA class
lncRNA
Alias
ENSG00000255717 ENSG00000255717.1 ENSG00000255717.2 ENSG00000255717.6 LINC00057 NCRNA00057 OTTHUMG00000167743.1 UHG lncRNA16
Location (GRCh38)
11:62851874-62856011
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation Other applications
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
SNHG1:55 UCUGCAGGAUUUACGCGCACGUUGGAACCGAAGAGAGCUCUGUUGUUGC… 535 nt 0.4542
SNHG1:56 UCUGCAGGAUUUACGCGCACGUUGGAACCGAAGAGAGCUCUGUUGUUGC… 579 nt 0.4318
SNHG1:57 UCUGCAGGAUUUACGCGCACGUUGGAACCGAAGAGAGCUCUGUUGUUGC… 769 nt 0.4304
SNHG1:58 UCUGCAGGAUUUACGCGCACGUUGGAACCGAAGAGAGCUCUGUUGUUGC… 526 nt 0.4544
SNHG1:59 UCUGCAGGAUUUACGCGCACGUUGGAACCGAAGAGAGCUCUGUUGUUGC… 539 nt 0.4453
SNHG1:6 ACUGCUCGUGGUAAGUGGCUUCGUGGUCUUUAUAGCUGUUACUCUUUUG… 1404 nt 0.4530
SNHG1:60 UCUGCAGGAUUUACGCGCACGUUGGAACCGAAGAGAGCUCUGUUGUUGC… 563 nt 0.4121
SNHG1:61 UCUGCAGGAUUUACGCGCACGUUGGAACCGAAGAGAGCUCUGUUGUUGC… 631 nt 0.4089
SNHG1:62 CAGAUGAUUUGAAUUGAUAAGCUGAUGUUCUGUGAGGUACAAAAGUUAA… 979 nt 0.4055
SNHG1:63 AUGAUGAAUCAAACUAGCUCACUAUGACCGACAGUGAAAAUACAUGAAC… 246 nt 0.4634
Showing 51 to 60 of 64 entries
Summary

This locus represents a small nucleolar RNA host gene that produces multiple alternatively spliced long non-coding RNAs. This gene is upregulated in cancers and is thought to act as promoter of cell proliferation. This transcript negatively regulates tumor suppressor genes such as tumor protein p53. Expression of this locus may be a marker of tumor progression. [provided by RefSeq, Dec 2017]

Forensic Context

A study in humans demonstrated that the SNHG1 was upregulated in subcutaneous adipose tissue during short-term weight loss [Bollepalli et al. DOI:10.1038/ijo.2017.245]. A review of non-coding RNAs in neurological diseases reported that the SNHG1 is detected in brain tissue of Parkinson's disease patients and is also investigated as a therapeutic target for such disorders [Das et al. DOI:10.1080/21655979.2021.2003667].