Basic Information

Symbol
XIST
RNA class
lncRNA
Alias
DXS1089 ENSG00000229807 ENSG00000229807.10 ENSG00000229807.3 ENSG00000229807.5 ENSG00000229807.9 LINC00001 NCRNA00001 OTTHUMG00000021839.3 XLOC_008185 linc-NAP1L2-4 swd66
Location (GRCh38)
X:73817775-73852753
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
XIST:28 AUAUUUCUUACUCUCUCGGGGCUGGAAGCUUCCUGACUGAAGAUCUCUC… 9200 nt 0.4077
XIST:29 AUAUUUCUUACUCUCUCGGGGCUGGAAGCUUCCUGACUGAAGAUCUCUC… 5302 nt 0.4510
XIST:3 CCUUCAGUUCUUAAAGCGCUGCAAUUCGCUGCUGCAGCCAUAUUUCUUA… 19280 nt 0.4121
XIST:30 AUAUUUCUUACUCUCUCGGGGCUGGAAGCUUCCUGACUGAAGAUCUCUC… 4313 nt 0.4572
XIST:31 AUAUUUCUUACUCUCUCGGGGCUGGAAGCUUCCUGACUGAAGAUCUCUC… 19236 nt 0.4119
XIST:32 AGCAGAAGAUGGAAUUAGACUGAUGACACACUGUCCAGCUACUCAGCGA… 2865 nt 0.4325
XIST:33 CCUACCCCCCUACCCCCCUCUGGUCUGCCCUGCACUGCACUGUUGCCAU… 16643 nt 0.4024
XIST:34 CCUACCCCCCUACCCCCCUCUGGUCUGCCCUGCACUGCACUGUUGCCAU… 16007 nt 0.4000
XIST:35 CCUACCCCCCUACCCCCCUCUGGUCUGCCCUGCACUGCACUGUUGCCAU… 2492 nt 0.4185
XIST:36 AGUGCUCCAGGCCUGCUUGGUGUGGACAUGGUGGUGAGCCGUGGCAAGG… 11477 nt 0.4327
Showing 21 to 30 of 70 entries
Summary

X inactivation is an early developmental process in mammalian females that transcriptionally silences one of the pair of X chromosomes, thus providing dosage equivalence between males and females. The process is regulated by several factors, including a region of chromosome X called the X inactivation center (XIC). The XIC comprises several non-coding and protein-coding genes, and this gene was the first non-coding gene identified within the XIC. This gene is expressed exclusively from the XIC of the inactive X chromosome, and is essential for the initiation and spread of X-inactivation. The transcript is a spliced RNA. Alternatively spliced transcript variants have been identified, but their full length sequences have not been determined. Mutations in the XIST promoter cause familial skewed X inactivation. [provided by RefSeq, Apr 2012]

Forensic Context

A study in humans demonstrated that the XIST was identified among transcripts important for predicting multiple organ failure/dysfunction syndrome (MOF/MODS) outcome from blood transcriptome analysis within 24 hours of traumatic injury using an XGBoost machine learning model [Duran et al. DOI:10.1186/s13613-024-01364-5]. A study in humans demonstrated that the XIST was significantly downregulated in peripheral blood mononuclear cells of patients with acute myocardial infarction compared to noncoronary artery controls, as identified by RNA sequencing and validated by quantitative real-time PCR [Zhao et al. DOI:10.1097/MD.0000000000012604].