Basic Information

Symbol
XIST
RNA class
lncRNA
Alias
DXS1089 ENSG00000229807 ENSG00000229807.10 ENSG00000229807.3 ENSG00000229807.5 ENSG00000229807.9 LINC00001 NCRNA00001 OTTHUMG00000021839.3 XLOC_008185 linc-NAP1L2-4 swd66
Location (GRCh38)
X:73817775-73852753
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
XIST:37 AGUGCUCCAGGCCUGCUUGGUGUGGACAUGGUGGUGAGCCGUGGCAAGG… 11309 nt 0.4328
XIST:38 AGUGCUCCAGGCCUGCUUGGUGUGGACAUGGUGGUGAGCCGUGGCAAGG… 11250 nt 0.4332
XIST:39 AGUGCUCCAGGCCUGCUUGGUGUGGACAUGGUGGUGAGCCGUGGCAAGG… 9486 nt 0.4339
XIST:4 CGGGGCUGGAAGCUUCCUGACUGAAGAUCUCUCUGCACUUGGGGUUCUU… 6098 nt 0.4362
XIST:40 AGUGCUCCAGGCCUGCUUGGUGUGGACAUGGUGGUGAGCCGUGGCAAGG… 9349 nt 0.4337
XIST:41 GGACAUGGUGGUGAGCCGUGGCAAGGACCAGAAUGGAUCACAGAUGAUC… 1734 nt 0.4475
XIST:42 AUUUAUAUUUAUCUUUUGGAUGUCAGUCAUACAGUCUGAUUUUGUGGUU… 19010 nt 0.4042
XIST:43 CCAGCCCUAGCCCCAGUCCCAGUCCUAGUUCCUCAGUCCCGCCCAGCUU… 10707 nt 0.4273
XIST:44 CCAGCCCUAGCCCCAGUCCCAGUCCUAGUUCCUCAGUCCCGCCCAGCUU… 11066 nt 0.4262
XIST:45 CCAGCCCUAGCCCCAGUCCCAGUCCUAGUUCCUCAGUCCCGCCCAGCUU… 10570 nt 0.4271
Showing 31 to 40 of 70 entries
Summary

X inactivation is an early developmental process in mammalian females that transcriptionally silences one of the pair of X chromosomes, thus providing dosage equivalence between males and females. The process is regulated by several factors, including a region of chromosome X called the X inactivation center (XIC). The XIC comprises several non-coding and protein-coding genes, and this gene was the first non-coding gene identified within the XIC. This gene is expressed exclusively from the XIC of the inactive X chromosome, and is essential for the initiation and spread of X-inactivation. The transcript is a spliced RNA. Alternatively spliced transcript variants have been identified, but their full length sequences have not been determined. Mutations in the XIST promoter cause familial skewed X inactivation. [provided by RefSeq, Apr 2012]

Forensic Context

A study in humans demonstrated that the XIST was identified among transcripts important for predicting multiple organ failure/dysfunction syndrome (MOF/MODS) outcome from blood transcriptome analysis within 24 hours of traumatic injury using an XGBoost machine learning model [Duran et al. DOI:10.1186/s13613-024-01364-5]. A study in humans demonstrated that the XIST was significantly downregulated in peripheral blood mononuclear cells of patients with acute myocardial infarction compared to noncoronary artery controls, as identified by RNA sequencing and validated by quantitative real-time PCR [Zhao et al. DOI:10.1097/MD.0000000000012604].