Basic Information

Symbol
XIST
RNA class
lncRNA
Alias
DXS1089 ENSG00000229807 ENSG00000229807.10 ENSG00000229807.3 ENSG00000229807.5 ENSG00000229807.9 LINC00001 NCRNA00001 OTTHUMG00000021839.3 XLOC_008185 linc-NAP1L2-4 swd66
Location (GRCh38)
X:73817775-73852753
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
XIST:64 AAGAUACCACGCUGCAUGUGUCCUUAGUAGUCAUGUCUCCUUAGGCUCC… 9677 nt 0.4001
XIST:65 AAGAUACCACGCUGCAUGUGUCCUUAGUAGUCAUGUCUCCUUAGGCUCC… 9609 nt 0.4000
XIST:66 AAAAGCUCACUACCACUGGGCAACAACCCUAGGUCAGGAGGUUCUGUCA… 402 nt 0.4279
XIST:67 AGUCAGCCUUCCCACCUGAAGAUCAACAUGCCUGGCACUCUAGCACUUG… 341 nt 0.3988
XIST:68 AGUCAGCCUUCCCACCUGAAGAUCAACAUGCCUGGCACUCUAGCACUUG… 6212 nt 0.3785
XIST:69 GUGUCUUGUCUUAGACAUAUCUCUCAUUUUUCAUUUUGUUGCUAUUUCU… 1723 nt 0.4417
XIST:7 CUGCACUGCACUGUUGCCAUGGGCAGUGCUCCAGGCCUGCUUGGUGUGG… 12117 nt 0.4272
XIST:70 GAAGACCUACAACCCAAGGAUGGAAGGCCCCUGUCACAAAGCCUACCUA… 453 nt 0.3642
XIST:8 GUGCUCCAGGCCUGCUUGGUGUGGACAUGGUGGUGAGCCGUGGCAAGGA… 16894 nt 0.4045
XIST:9 UGUGGACAUGGUGGUGAGCCGUGGCAAGGACCAGAAUGGAUCACAGAUG… 2637 nt 0.4334
Showing 61 to 70 of 70 entries
Summary

X inactivation is an early developmental process in mammalian females that transcriptionally silences one of the pair of X chromosomes, thus providing dosage equivalence between males and females. The process is regulated by several factors, including a region of chromosome X called the X inactivation center (XIC). The XIC comprises several non-coding and protein-coding genes, and this gene was the first non-coding gene identified within the XIC. This gene is expressed exclusively from the XIC of the inactive X chromosome, and is essential for the initiation and spread of X-inactivation. The transcript is a spliced RNA. Alternatively spliced transcript variants have been identified, but their full length sequences have not been determined. Mutations in the XIST promoter cause familial skewed X inactivation. [provided by RefSeq, Apr 2012]

Forensic Context

A study in humans demonstrated that the XIST was identified among transcripts important for predicting multiple organ failure/dysfunction syndrome (MOF/MODS) outcome from blood transcriptome analysis within 24 hours of traumatic injury using an XGBoost machine learning model [Duran et al. DOI:10.1186/s13613-024-01364-5]. A study in humans demonstrated that the XIST was significantly downregulated in peripheral blood mononuclear cells of patients with acute myocardial infarction compared to noncoronary artery controls, as identified by RNA sequencing and validated by quantitative real-time PCR [Zhao et al. DOI:10.1097/MD.0000000000012604].