Basic Information

Symbol
H19
RNA class
lncRNA
Alias
ASM ASM1 D11S813E ENSG00000130600 ENSG00000130600.11 ENSG00000130600.15 ENSG00000130600.16 ENSG00000130600.17 ENSG00000130600.18 ENSG00000130600.9 LINC00008 NCRNA00008 OTTHUMG00000012477.4
Location (GRCh38)
11:1995130-2001710
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
H19:19 UCUGUUUCCCCCGUCCCUUCUGAAUUUAAUUUGCACUAAGUCAUUUGCA… 376 nt 0.5904
H19:2 CAUCAGAGGACCAUGGCCCCGUAUCACCUGGGUCAGGCACUGAAGCUGG… 736 nt 0.5856
H19:20 CAUCAGAGGACCAUGGCCCCGUAUCACCUGGGUCAGGCACUGAAGCUGG… 989 nt 0.5683
H19:21 AGAGGACCAUGGCCCCGUAUCACCUGGGUCAGGCACUGAAGCUGGGACA… 1239 nt 0.5819
H19:22 AGUGUUCCUGGAGUCUCGCUGCCCAGAUGCCACGGAAUCAGUUGAAGGA… 554 nt 0.6444
H19:23 AGUUAGAAAAAGCCCGGGCUAGGACCGAGGAGCAGGGACGUGGCAGCUG… 475 nt 0.6547
H19:24 AGUUAGAAAAAGCCCGGGCUAGGACCGAGGAGCAGGGUGAGGGAGGGGG… 2342 nt 0.6345
H19:25 ACAGCAUCCAGGGGAGUCAAGGGCAUGGGGCGAGACCAGACUAGGCGAG… 1090 nt 0.6220
H19:26 ACAACCAACACGUUCUCCCCACACGACUCUCUCGUUCUCCCCACAGCCA… 592 nt 0.5963
H19:27 GUGUCUGCCCUCCCUGCGUCAGGACGCGGCCCUGCCCAGACCGCCCCGC… 489 nt 0.5971
Showing 11 to 20 of 27 entries
Summary

This gene is located in an imprinted region of chromosome 11 near the insulin-like growth factor 2 (IGF2) gene. This gene is only expressed from the maternally-inherited chromosome, whereas IGF2 is only expressed from the paternally-inherited chromosome. The product of this gene is a long non-coding RNA which functions as a tumor suppressor. Mutations in this gene have been associated with Beckwith-Wiedemann Syndrome and Wilms tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Forensic Context

A study in mice demonstrated that the long non-coding RNA H19 plays multiple functions during myocardial ischemic injury [Luo et al. DOI:10.3389/fcell.2021.615950]. A study in Phormia regina maggots demonstrated that the H19 (asm), an RNA marker associated with sphingolipid metabolism and cellular development, was upregulated as maggots aged from 80 to 130 hours at 27.5 °C, and its expression pattern was consistently identified by differential gene expression, weighted gene co-expression network, and generalized linear model analyses as delineating maggot age for postmortem interval estimation [Lin et al. DOI:10.1371/journal.pgen.1011948].