Basic Information

Symbol
ZFAS1
RNA class
lncRNA
Alias
1500012F01Rik ENSG00000177410 ENSG00000177410.12 ENSG00000177410.8 HSUP1 HSUP2 NCRNA00275 OTTHUMG00000032698.3 ZNFX1-AS1 Znfx1 antisense
Location (GRCh38)
20:49276739-49361131
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
ZFAS1:1 CGGGGGCCCAGGGUGGAGAGCACGAGGGCCUGGCCCAGGCACGGCCGGC… 946 nt 0.5698
ZFAS1:10 UGCGCAGGUGCGAAAGCCAUCUUUGGUUAUAUAAGGGAGGUUCAGGAAG… 604 nt 0.4520
ZFAS1:11 UGCGCAGGUGCGAAAGCCAUCUUUGGUUAUAUAAGGGAGGUUCAGGAAG… 542 nt 0.4465
ZFAS1:12 CUUUCGCGUCUGCGGUGCCCGGAGUGUGGUACUUCUCCUAGUUGCAGUC… 504 nt 0.4425
ZFAS1:13 CUUUCGCGUCUGCGGUGCCCGGAGUGUGGUACUUCUCCUAGUUGCAGUC… 566 nt 0.4488
ZFAS1:14 CUUUCGCGUCUGCGGUGCCCGGAGUGUGGUACUUCUCCUAGUUGCAGUC… 767 nt 0.4394
ZFAS1:15 CUUUCGCGUCUGCGGUGCCCGGAGUGUGGUACUUCUCCUAGUUGCAGUC… 502 nt 0.4442
ZFAS1:16 CGGUGCCCGGAGUGUGGUACUUCUCCUAGUUGCAGUCAGGCUUCAUACG… 508 nt 0.5059
ZFAS1:17 CGUGCAGACAUCUACAACCUUCGAUCUCCUGACGAGUUUAUUGUUGGCC… 732 nt 0.4385
ZFAS1:18 CCUUCCCAGGUAUUGGCAACACCAGAAGUCCAGUUGGUCAGGAGCUGUG… 597 nt 0.5042
Showing 1 to 10 of 30 entries
Summary

This gene represents a snoRNA host gene that produces a non-coding RNA. Increased expression or amplification of this locus is associated with cancer progression and metastasis. This transcript regulates expression of genes involved in differentiation. It may act a molecular sponge for microRNAs. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Dec 2017]

Forensic Context

A study in mice demonstrated that the ZFAS1 is upregulated following traumatic brain injury, and its inhibition reduces inflammatory response, apoptosis, and recovers neurological function [Li et al. DOI:10.1016/j.neuint.2023.105643]. In cardiovascular research, the ZFAS1 is upregulated in ischemic heart failure, causing impaired contractile function by repressing SERCA2a expression and leading to intracellular calcium overload [Chih-Fan Yeh et al. DOI:10.1186/s12929-020-00647-w].