Basic Information

Symbol
ZFAS1
RNA class
lncRNA
Alias
1500012F01Rik ENSG00000177410 ENSG00000177410.12 ENSG00000177410.8 HSUP1 HSUP2 NCRNA00275 OTTHUMG00000032698.3 ZNFX1-AS1 Znfx1 antisense
Location (GRCh38)
20:49276739-49361131
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
ZFAS1:29 CUUUGAUUGAACCAGGAUGAAUGCGGGUGUUGGAAGUAGAAUAUAUAUA… 847 nt 0.4345
ZFAS1:3 CGGGGGCCCAGGGUGGAGAGCACGAGGGCCUGGCCCAGGCACGGCCGGC… 860 nt 0.5919
ZFAS1:30 CUUUGAUUGAACCAGGAUGAAUGCGGGUGUUGGAAGUAGAAUAUAUAUA… 1003 nt 0.4267
ZFAS1:31 CGGGGGCCCAGGGUGGAGAGCACGAGGGCCUGGCCCAGGCACGGCCGGC… 689 nt 0.5414
ZFAS1:4 CGGGGGCCCAGGGUGGAGAGCACGAGGGCCUGGCCCAGGCACGGCCGGC… 1008 nt 0.5655
ZFAS1:5 CGGGGGCCCAGGGUGGAGAGCACGAGGGCCUGGCCCAGGCACGGCCGGC… 687 nt 0.5429
ZFAS1:6 CGGGGGCCCAGGGUGGAGAGCACGAGGGCCUGGCCCAGGCACGGCCGGC… 944 nt 0.5710
ZFAS1:7 CGGGGGCCCAGGGUGGAGAGCACGAGGGCCUGGCCCAGGCACGGCCGGC… 858 nt 0.5932
ZFAS1:8 CGGGGGCCCAGGGUGGAGAGCACGAGGGCCUGGCCCAGGCACGGCCGGC… 1006 nt 0.5666
ZFAS1:9 CGGAGCCGGCGGGCUCAGGCGGGCGCGGCUGAGGGGAGCGGACCGCGGG… 596 nt 0.5000
Showing 21 to 30 of 30 entries
Summary

This gene represents a snoRNA host gene that produces a non-coding RNA. Increased expression or amplification of this locus is associated with cancer progression and metastasis. This transcript regulates expression of genes involved in differentiation. It may act a molecular sponge for microRNAs. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Dec 2017]

Forensic Context

A study in mice demonstrated that the ZFAS1 is upregulated following traumatic brain injury, and its inhibition reduces inflammatory response, apoptosis, and recovers neurological function [Li et al. DOI:10.1016/j.neuint.2023.105643]. In cardiovascular research, the ZFAS1 is upregulated in ischemic heart failure, causing impaired contractile function by repressing SERCA2a expression and leading to intracellular calcium overload [Chih-Fan Yeh et al. DOI:10.1186/s12929-020-00647-w].