Basic Information

Symbol
HAND2-AS1
RNA class
lncRNA
Alias
DEIN ENSG00000237125.3 ENSG00000237125.4 ENSG00000237125.8 ENSG00000237125.9 FLJ11539 NBLA00301 OTTHUMG00000160783.5 RP11-471J12.1
Location (GRCh38)
4:173530353-173591470
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
HAND2-AS1:115 GAUUGGCUACCUCCUCAUAACCAUAAGAUAAUUAAAACUUGGCGGGGGG… 4441 nt 0.4272
HAND2-AS1:116 GAUUGGCUACCUCCUCAUAACCAUAAGAUAAUUAAAACUUGGCGGGGGG… 4484 nt 0.4255
HAND2-AS1:117 GAUUGGCUACCUCCUCAUAACCAUAAGAUAAUUAAAACUUGGCGGGGGG… 4974 nt 0.4326
HAND2-AS1:118 GAUUGGCUACCUCCUCAUAACCAUAAGAUAAUUAAAACUUGGCGGGGGG… 4162 nt 0.4202
HAND2-AS1:119 GAUUGGCUACCUCCUCAUAACCAUAAGAUAAUUAAAACUUGGCGGGGGG… 5141 nt 0.4355
HAND2-AS1:12 GGAUAAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCC… 840 nt 0.4095
HAND2-AS1:120 GAUUGGCUACCUCCUCAUAACCAUAAGAUAAUUAAAACUUGGCGGGGGG… 4274 nt 0.4235
HAND2-AS1:121 GAUUGGCUACCUCCUCAUAACCAUAAGAUAAUUAAAACUUGGCGGGGGG… 4971 nt 0.4327
HAND2-AS1:122 GAUUGGCUACCUCCUCAUAACCAUAAGAUAAUUAAAACUUGGCGGGGGG… 743 nt 0.4401
HAND2-AS1:123 GGAUAAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCC… 868 nt 0.3698
Showing 11 to 20 of 100 entries
Summary

Predicted to be involved in positive regulation of gene expression. Predicted to act upstream of or within with a positive effect on cardiac right ventricle morphogenesis. Predicted to act upstream of or within transcription elongation by RNA polymerase II. Predicted to be located in chromatin; cytoplasm; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A review of single-cell RNA sequencing in the heart identified the HAND2-AS1 as a long non-coding RNA that regulates the expression of the transcription factor Hand2 to orchestrate heart development [Yamada & Nomura DOI:10.3390/ijms21218345]. A consensus statement on long non-coding RNAs further notes that the HAND2-AS1, also known as Upperhand, orchestrates heart development through the regulation of precise Hand2 expression [Mattick et al. DOI:10.1038/s41580-022-00566-8]. A review of long noncoding RNAs in cardiovascular diseases noted that the HAND2-AS1 is involved in cardiac development and functions in reprogramming cardiac fibroblasts into cardiomyocytes by upregulating the expression of HAND2 [Chih-Fan Yeh et al. DOI:10.1186/s12929-020-00647-w].