Basic Information

Symbol
HAND2-AS1
RNA class
lncRNA
Alias
DEIN ENSG00000237125.3 ENSG00000237125.4 ENSG00000237125.8 ENSG00000237125.9 FLJ11539 NBLA00301 OTTHUMG00000160783.5 RP11-471J12.1
Location (GRCh38)
4:173530353-173591470
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
HAND2-AS1:124 AAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCCCCAA… 1763 nt 0.4453
HAND2-AS1:125 AUUGAAGAAUCUCUAACCAGAAGGCACAGAUCAUUCAUGGGGAUGUAUA… 830 nt 0.3964
HAND2-AS1:126 GAGGAGCGGCUGGAGAAGGGUGUUUCUUUGACCCGUUUACAGGCUCGAA… 426 nt 0.5282
HAND2-AS1:127 GCCUGUUUGUGGAAGUGACUCUGACCGUUCCCUUAAGAAUCUUUAAUGC… 663 nt 0.4827
HAND2-AS1:128 AGUCCUUUCCUUGCUCACCGCCGACAAAGUGGUUGGGGCAGGAAGGCGA… 3015 nt 0.4551
HAND2-AS1:129 ACAGUGACCUGAGUGCACGCACCCAAGCCGGCAGGCCACUCUAGAAAAC… 1186 nt 0.4182
HAND2-AS1:13 GGAUAAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCC… 1382 nt 0.5890
HAND2-AS1:130 GUGGAAAGUAUUAGAAACAUGAUUGUGUUUGCAAAGGGAGACAUAAACG… 638 nt 0.4655
HAND2-AS1:14 GGAUAAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCC… 358 nt 0.3883
HAND2-AS1:15 GGAUAAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCC… 561 nt 0.3494
Showing 21 to 30 of 100 entries
Summary

Predicted to be involved in positive regulation of gene expression. Predicted to act upstream of or within with a positive effect on cardiac right ventricle morphogenesis. Predicted to act upstream of or within transcription elongation by RNA polymerase II. Predicted to be located in chromatin; cytoplasm; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A review of single-cell RNA sequencing in the heart identified the HAND2-AS1 as a long non-coding RNA that regulates the expression of the transcription factor Hand2 to orchestrate heart development [Yamada & Nomura DOI:10.3390/ijms21218345]. A consensus statement on long non-coding RNAs further notes that the HAND2-AS1, also known as Upperhand, orchestrates heart development through the regulation of precise Hand2 expression [Mattick et al. DOI:10.1038/s41580-022-00566-8]. A review of long noncoding RNAs in cardiovascular diseases noted that the HAND2-AS1 is involved in cardiac development and functions in reprogramming cardiac fibroblasts into cardiomyocytes by upregulating the expression of HAND2 [Chih-Fan Yeh et al. DOI:10.1186/s12929-020-00647-w].