Basic Information

Symbol
HAND2-AS1
RNA class
lncRNA
Alias
DEIN ENSG00000237125.3 ENSG00000237125.4 ENSG00000237125.8 ENSG00000237125.9 FLJ11539 NBLA00301 OTTHUMG00000160783.5 RP11-471J12.1
Location (GRCh38)
4:173530353-173591470
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
HAND2-AS1:16 GGAUAAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCC… 883 nt 0.4020
HAND2-AS1:17 GGAUAAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCC… 3273 nt 0.3614
HAND2-AS1:18 GGAUAAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCC… 5278 nt 0.4382
HAND2-AS1:19 GGAUAAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCC… 502 nt 0.4701
HAND2-AS1:20 GGAUAAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCC… 766 nt 0.3825
HAND2-AS1:21 GAUAAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCCC… 2428 nt 0.5325
HAND2-AS1:22 GAUAAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCCC… 2420 nt 0.5339
HAND2-AS1:23 AUAAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCCCC… 951 nt 0.4522
HAND2-AS1:24 AUAAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCCCC… 557 nt 0.5189
HAND2-AS1:25 AAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCCCCAA… 514 nt 0.4942
Showing 31 to 40 of 100 entries
Summary

Predicted to be involved in positive regulation of gene expression. Predicted to act upstream of or within with a positive effect on cardiac right ventricle morphogenesis. Predicted to act upstream of or within transcription elongation by RNA polymerase II. Predicted to be located in chromatin; cytoplasm; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A review of single-cell RNA sequencing in the heart identified the HAND2-AS1 as a long non-coding RNA that regulates the expression of the transcription factor Hand2 to orchestrate heart development [Yamada & Nomura DOI:10.3390/ijms21218345]. A consensus statement on long non-coding RNAs further notes that the HAND2-AS1, also known as Upperhand, orchestrates heart development through the regulation of precise Hand2 expression [Mattick et al. DOI:10.1038/s41580-022-00566-8]. A review of long noncoding RNAs in cardiovascular diseases noted that the HAND2-AS1 is involved in cardiac development and functions in reprogramming cardiac fibroblasts into cardiomyocytes by upregulating the expression of HAND2 [Chih-Fan Yeh et al. DOI:10.1186/s12929-020-00647-w].