Basic Information

Symbol
HAND2-AS1
RNA class
lncRNA
Alias
DEIN ENSG00000237125.3 ENSG00000237125.4 ENSG00000237125.8 ENSG00000237125.9 FLJ11539 NBLA00301 OTTHUMG00000160783.5 RP11-471J12.1
Location (GRCh38)
4:173530353-173591470
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
HAND2-AS1:35 GAUGCUUCACUAUUAAAAUAUUUUCCCCCCAAGUCUCAAAUAUUGAAGA… 837 nt 0.4659
HAND2-AS1:36 UUCACUAUUAAAAUAUUUUCCCCCCAAGUCUCAAAUAUUGAAGAAUCUC… 971 nt 0.4954
HAND2-AS1:37 CCCCCAAGUCUCAAAUAUUGAAGAAUCUCUAACCAGAAGGCACAGAUCA… 949 nt 0.5100
HAND2-AS1:38 CCCCCAAGUCUCAAAUAUUGAAGAAUCUCUAACCAGAAGGCACAGAUCA… 621 nt 0.5072
HAND2-AS1:39 CCAAGUCUCAAAUAUUGAAGAAUCUCUAACCAGGGACACCAGUCCCUAC… 455 nt 0.4901
HAND2-AS1:4 GAUUGGCUACCUCCUCAUAACCAUAAGAUAAUUAAAACUUGGCGGGGGG… 1315 nt 0.5833
HAND2-AS1:40 CAAAUAUUGAAGAAUCUCUAACCAGGCUCGAAACGCCGGUCUCAGUGGC… 892 nt 0.4989
HAND2-AS1:41 CAGUAUCACUCUGCUCUCUUUUCUGGUUGAAAAGAAAGAAAGAAAGAAA… 1417 nt 0.5201
HAND2-AS1:42 GCCCCAGCAGGGACGAGGAGCGGCUGGAGAAGGGUGUUUCUUUGACCCG… 1641 nt 0.5777
HAND2-AS1:43 AUAAAAGCGGGCAUCUGUGGAAAGCAGGUUUAGUUAUCGGAGGGGAACC… 635 nt 0.4724
Showing 51 to 60 of 100 entries
Summary

Predicted to be involved in positive regulation of gene expression. Predicted to act upstream of or within with a positive effect on cardiac right ventricle morphogenesis. Predicted to act upstream of or within transcription elongation by RNA polymerase II. Predicted to be located in chromatin; cytoplasm; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A review of single-cell RNA sequencing in the heart identified the HAND2-AS1 as a long non-coding RNA that regulates the expression of the transcription factor Hand2 to orchestrate heart development [Yamada & Nomura DOI:10.3390/ijms21218345]. A consensus statement on long non-coding RNAs further notes that the HAND2-AS1, also known as Upperhand, orchestrates heart development through the regulation of precise Hand2 expression [Mattick et al. DOI:10.1038/s41580-022-00566-8]. A review of long noncoding RNAs in cardiovascular diseases noted that the HAND2-AS1 is involved in cardiac development and functions in reprogramming cardiac fibroblasts into cardiomyocytes by upregulating the expression of HAND2 [Chih-Fan Yeh et al. DOI:10.1186/s12929-020-00647-w].