Basic Information

Symbol
HAND2-AS1
RNA class
lncRNA
Alias
DEIN ENSG00000237125.3 ENSG00000237125.4 ENSG00000237125.8 ENSG00000237125.9 FLJ11539 NBLA00301 OTTHUMG00000160783.5 RP11-471J12.1
Location (GRCh38)
4:173530353-173591470
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
HAND2-AS1:72 GCCGAGGUCCUCUUCCAGGAUUGGCUACCUCCUCAUAACCAUAAGAUAA… 22261 nt 0.3900
HAND2-AS1:73 GCCGAGGUCCUCUUCCAGGAUUGGCUACCUCCUCAUAACCAUAAGAUAA… 1429 nt 0.4983
HAND2-AS1:74 AAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCCCCAA… 354 nt 0.3870
HAND2-AS1:75 AAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCCCCAA… 514 nt 0.4942
HAND2-AS1:76 AAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCCCCAA… 522 nt 0.4808
HAND2-AS1:77 AAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCCCCAA… 805 nt 0.5019
HAND2-AS1:78 AAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCCCCAA… 809 nt 0.5006
HAND2-AS1:79 AAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCCCCAA… 993 nt 0.4924
HAND2-AS1:8 GGAUAAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCC… 867 nt 0.3702
HAND2-AS1:80 AAUGCAAGUGUUUAACAGAUGCUUCACUAUUAAAAUAUUUUCCCCCCAA… 583 nt 0.4940
Showing 71 to 80 of 100 entries
Summary

Predicted to be involved in positive regulation of gene expression. Predicted to act upstream of or within with a positive effect on cardiac right ventricle morphogenesis. Predicted to act upstream of or within transcription elongation by RNA polymerase II. Predicted to be located in chromatin; cytoplasm; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A review of single-cell RNA sequencing in the heart identified the HAND2-AS1 as a long non-coding RNA that regulates the expression of the transcription factor Hand2 to orchestrate heart development [Yamada & Nomura DOI:10.3390/ijms21218345]. A consensus statement on long non-coding RNAs further notes that the HAND2-AS1, also known as Upperhand, orchestrates heart development through the regulation of precise Hand2 expression [Mattick et al. DOI:10.1038/s41580-022-00566-8]. A review of long noncoding RNAs in cardiovascular diseases noted that the HAND2-AS1 is involved in cardiac development and functions in reprogramming cardiac fibroblasts into cardiomyocytes by upregulating the expression of HAND2 [Chih-Fan Yeh et al. DOI:10.1186/s12929-020-00647-w].