Basic Information

Symbol
HOTAIRM1
RNA class
lncRNA
Alias
ENSG00000233429.4 ENSG00000233429.5 ENSG00000233429.9 HOXA-AS1 HOXA1-AS1 NCRNA00179 OTTHUMG00000158089.3
Location (GRCh38)
7:27096080-27100265
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses Sudden death from CNS diseases
External database
HGNC NCBI Ensembl LNCipedia RNAcentral

Transcripts

ID Sequence Length GC content
HOTAIRM1:9 AAACAGGUUUAAGAAUGAAAUAUUGAUUUUUCUGACCCUGAAAAAAAAA… 647 nt 0.3555
Showing 11 to 11 of 11 entries
Summary

This non-coding locus is located in the HOX gene cluster. Transcription of this locus is induced by retinoic acid, and transcripts likely function in regulation of myelopoiesis through transcriptional activation of several genes in the HOXA cluster, in addition to several beta-2 integrins. [provided by RefSeq, Jan 2013]

Forensic Context

A study in human postmortem midbrain specimens from chronic cocaine abusers identified the HOTAIRM1 as an up-regulated long noncoding RNA, with a 1.53-fold increase in expression compared to well-matched control subjects [Bannon et al. DOI:10.1111/jnc.13255]. A separate review also lists the HOTAIRM1 as a biomarker detected in circulating PBMCs of Parkinson's disease patients [Das et al. DOI:10.1080/21655979.2021.2003667].