Basic Information
Symbol
HOTTIP
RNA class
lncRNA
Alias
ENSG00000243766
ENSG00000243766.2
ENSG00000243766.3
ENSG00000243766.7
ENSG00000243766.8
ENSG00000253769
HOXA-AS6
HOXA13-AS1
OTTHUMG00000063751.5
RP1-170O19.3
Location (GRCh38)
7:27198575-27207259
Forensic tag(s)
Other applications
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| HOTTIP:1 | UGCUAAAGCCUAGAGGGUCAGUGGGGAAGGUAGUUAGUUCUGAACUGAA… | 781 nt | 0.5403 |
| HOTTIP:10 | AGUGUGCCCUUUCCUUCUUGACUUUUUAGCAGUUCUGGGUAAAUAUUGA… | 3343 nt | 0.5088 |
| HOTTIP:2 | CCCUUCCUUUAUCCCAGUGGGGCCCAGACCCGCGCAACCAGGCGGGGAG… | 4511 nt | 0.5192 |
| HOTTIP:3 | CCCUUCCUUUAUCCCAGUGGGGCCCAGACCCGCGCAACCAGGCGGGGAG… | 4665 nt | 0.5203 |
| HOTTIP:4 | CCCUUCCUUUAUCCCAGUGGGGCCCAGACCCGCGCAACCAGGCGGGGAG… | 1166 nt | 0.5489 |
| HOTTIP:5 | GUGGGGCCCAGACCCGCGCAACCAGGCGGGGAGGGGAGGUGGGCGCGCG… | 2285 nt | 0.5400 |
| HOTTIP:6 | GUGGGGCCCAGACCCGCGCAACCAGGCGGGGAGGGGAGGUGGGCGCGCG… | 1286 nt | 0.5467 |
| HOTTIP:7 | CAAGUGUGCCCUUUCCUUCUUGACUUUUUAGCAGUUCUGGGUAAAUAUU… | 3345 nt | 0.5088 |
| HOTTIP:8 | ACAGUGACAAAGAGACAGAGUAGGGUUCUAGGCCCCUGUUCCUGGGGAC… | 3157 nt | 0.5109 |
Summary
This gene produces a long RNA in antisense to the HOXA gene cluster. This transcript may regulate expression of HOXA genes in cis. This gene is upregulated in tumors and is implicated in the promotion of cell proliferation. [provided by RefSeq, Dec 2017]
Forensic Context
A study in mice demonstrated that the HOTTIP activates expression of HOXA9-HOXA13 genes to promote distal limb development by recruiting the WDR5 subunit of the MLL complex to enforce an active chromatin state and is expressed at low copy number [Flynn and Chang DOI:10.1016/j.stem.2014.05.014].