Basic Information

Symbol
DCD
RNA Class
mRNA
Alias
dermcidin AIDD PIF DSEP HCAP DCD-1 proteolysis inducing factor preproteolysin diffusible survival/evasion peptide survival promoting peptide Dermcidin Preproteolysin EC 3.4.-.-
Location (GRCh38)
12:54644589-54648493 UCSC Genome Browser
Transcripts
NM_001300854.2
BLAST PRIMER
NM_053283.4
BLAST PRIMER
External Database
HGNC NCBI Ensembl UniProt OMIM GTEx

Secondary Structure

MANE Select
NM_053283.4
Sequence length
519 nt
GC Content
0.4798

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-147.4 kcal/mol
Thermodynamic ensemble
Free Energy: -156.76 kcal/mol
Frequency: 0.0000
Diversity: 105.12
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.....(((((.(((..((.(((((..(((....((((.....))))))).((........))...(((((...((.((((..((((((......((((((...(((((((((((..((((......((((((...))))))((((......))))...((((.....(..((....))..)....)))).......))))..))).)))))))).))))))..(((......))).))))))..)))))).)))))(((((........)))))((.(((.......))).)).))))))).)))...)))))...((((((.(((((..(((((.......)))))...(((....)))..((((((...)))))).)))))(((((...((((((((........((((.....((.....))....))))(((((..........)))))....................................))))))))...)))))..))))))......
Thermodynamic Ensemble Prediction
.....(((((.(((,.((.(((((..(({..,(((({.....)))})}}.{{.....,..}|,{(({,,|},}|,.((((..((((((....,.((((((...(((((((((((..((((......((((((...))))))((((......))))...{{{(,,..,{,.{{....||,,}||..,}))....,,,))))..)))})})))))).))))))..(((......))).))))))..))))}},|||||{{{{{........}}}},{|,(((.......))).)).))))))).))}...)))))...((((((.((({{.,(((({.......}}}}}...{{{....}))..((((((...)))))).))))){((((...((((((((.,{{....(((({,,..((,....},....},,),||{|},,..},,.})))}}....}}}.......................,}}...))))))))...))))}..))))))......

Transcripts

ID Sequence Length GC Content
NM_001300854.2 GACACCCUAGAUCCCAAGAUCUCCAAGGAUUUGGUGGCAUACCCACUCC… 583 nt 0.4854
NM_053283.4 GACACCCUAGAUCCCAAGAUCUCCAAGGAUUUGGUGGCAUACCCACUCC… 519 nt 0.4798
Summary

This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Forensic Context

No forensic context available.

Genomic Tracks
Track Image