Basic Information

Symbol
DEFA5
RNA Class
mRNA
Alias
defensin alpha 5 HD-5 defensin, alpha 5, Paneth cell-specific DEF5 HD5(20-94) defensin, alpha 5, preproprotein defensin-5 Defensin alpha 5 Defensin-5
Location (GRCh38)
8:7055304-7056739 UCSC Genome Browser
Transcripts
NM_021010.3
BLAST PRIMER
External Database
HGNC NCBI Ensembl UniProt OMIM GTEx

Secondary Structure

MANE Select
NM_021010.3
Sequence length
454 nt
GC Content
0.5110

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-142.4 kcal/mol
Thermodynamic ensemble
Free Energy: -149 kcal/mol
Frequency: 0.0000
Diversity: 89.26
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.........(((..(((((...(((((..((((((..(((((.((.((.((...((.......(((((((......)))))))...)).))))))))))).)))))).))))).)))))....)))(((....((((((.....)))))).........((((((((((((((((.....(((((...(((.((((.(((.((.((((((...)))))).)))))))))))))))))....((((...)))).((..((((.((((.(((.....)))))))((.((.(((.((((((((.((.............)).))))))))..))).)).)).........))))..)).))))..))..)))))))))).....(((((.((((..(((.....)))....)))).)))))...........................)))......
Thermodynamic Ensemble Prediction
.........{((..(((((...(((((..((((((..(((((.((.((.((...({.......(((((((......}))))))...)),))))))))))).)))))).))))).))))).}..}}}(({....((((((.....)))))){{{{{,...(((((((((({{{{({.....(((((...(((.((((.(((.((.((((((...)))))).)))))))))))))))))....(({(...||||,{{(((((({((({.(((.....)))}}))}}},|,|,,.{|||||||,|{.||....{.,...}}.))}))})),,||}.,},},.,........}}}},)},})}}..}}..)))))))))).....(({{{.((((..{((.....))}....)))),))))}......................,,...}})......

Transcripts

ID Sequence Length GC Content
NM_021010.3 ACAUAUCCACUCCUGCUCUCCCUCCUGCAGGUGACCCCAGCCAUGAGGA… 454 nt 0.5110
Summary

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. [provided by RefSeq, Oct 2014]

Forensic Context

No forensic context available.

Genomic Tracks
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