Basic Information

Symbol
DEFA6
RNA Class
mRNA
Alias
defensin alpha 6 HD-6 DEF6 defensin, alpha 6, Paneth cell-specific defensin-6 Defensin-6 Defensin, alpha 6
Location (GRCh38)
8:6924697-6926076 UCSC Genome Browser
Transcripts
NM_001926.4
BLAST PRIMER
External Database
HGNC NCBI Ensembl UniProt OMIM GTEx

Secondary Structure

MANE Select
NM_001926.4
Sequence length
465 nt
GC Content
0.4882

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-143.6 kcal/mol
Thermodynamic ensemble
Free Energy: -150.92 kcal/mol
Frequency: 0.0000
Diversity: 114.95
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...(((.(((((((((((((.........((.......))..((((....)))).((((((((..(((((((.(((..(((((.....))))))))..)))).......))))))))))).....(((..((((..(((((...)))))..)))))))))).)))).)))))).)))...(((((((((............((((((..(((((...(((((((.(((((...)))))....)))))))...)))))(((.((((.((((((((((((((....))))).....)))))))))...)))).)))(((....))).(((......))))))))).(((((((((((((((..........((((((......))))))......((((.((......)).))))...............)))))))..))))))))...)))))))))........
Thermodynamic Ensemble Prediction
.,,(,,{((((((((,,{,,,,.,,,,..((.......}}..{(((....)))}.((((((((..(((((((.(((..(((((.....))))))))..)))).......))))))))))).......,..((((..((((,...)))))..))))))))))})),)})}|||,..||,..(((((((((.....,{{{,..{{{{{{,.{{((({{({{{{....|||||},,|||||..,,|}}})}}...,}})||,|,||{{.((((((((((((((....))))).....))))))))),,,,}||{,||(({....})).|||},..})).,)))))).(((((((((((((((.,,.......((((((......)))))),,,...|||,.,{.,,.{{||{|,,,,}}}}}.},......))))))),.))))))))...))))))))).,,,....

Transcripts

ID Sequence Length GC Content
NM_001926.4 ACACAUCUGCUCCUGCUCUCUCUCCUCCAGCGACCCUAGCCAUGAGAAC… 465 nt 0.4882
Summary

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel. [provided by RefSeq, Oct 2014]

Forensic Context

No forensic context available.

Genomic Tracks
Track Image