Basic Information
Symbol
DEFB1
RNA Class
mRNA
Alias
defensin beta 1
HBD-1
DEFB-1
DEFB101
HBD1
BD1
MGC51822
beta-defensin 1
beta defensin 1
defensin, beta 1
BD-1
Beta-defensin 1
hBD-1
Defensin, beta 1
Location (GRCh38)
8:6870592-6877936
UCSC Genome Browser
Transcripts
Secondary Structure
MANE Select
NM_005218.4
Sequence length
375 nt
GC Content
0.4693
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-105.1 kcal/mol
Thermodynamic ensemble
Free Energy:
-112.36 kcal/mol
Frequency:
0.0000
Diversity:
82.0
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..((..(((.(((..((((.((((..(((..(((...((....))...)))...))))))).)))).))).)))..))(((....(((((.....((((.(((.((((((((.((((((((....(((((.....)))))((((........)))).((((((((((......(((((((.......)).))))).((((((((......)))))))).(((((......................)))))(((.......)))...))))))).)))..)))))))).)))))))).))).))))........)))))...))).(((((....((((((((((((...)))))))...)))))..)))))...
Thermodynamic Ensemble Prediction
..((..(((.(((..((((.(((..{(((..(((.,.{{....})..,)))...))))))).)))).))).)))..))(((....(((((.....((((.(((.((((((((.((((((({.,,,{((((...,,|}}}}{{||,.....,,)))|,((((((((((.....,{(({{{,.......||,}}}}|||({(((((......}))))},.,||||({{{.{{..,,.........},.,)))}(((.....,.)))...))))))).)))},)))))))).)))))))).))).))))........)))))...))).{((((,,,.(((((((((((,...))))))}...)))))..)))))...
Transcripts
| ID | Sequence | Length | GC Content |
|---|---|---|---|
| NM_005218.4 | AAGCCUCUGUCAGCUCAGCCUCCAAAGGAGCCAGCGUCUCCCCAGUUCC… | 375 nt | 0.4693 |
Summary
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008]
Forensic Context
No forensic context available.
Genomic Tracks
