Basic Information

Symbol
AHSG
RNA Class
mRNA
Alias
alpha 2-HS glycoprotein FETUA A2HS HSGA fetuin A AHS APMR1 alpha-2-HS-glycoprotein alpha-2-Z-globulin ba-alpha-2-glycoprotein fetuin-A Alpha-2-HS-glycoprotein Alpha-2-Z-globulin Ba-alpha-2-glycoprotein Fetuin-A
Location (GRCh38)
3:186612776-186621318 UCSC Genome Browser
Transcripts
NM_001354571.2
BLAST PRIMER
NM_001354572.2
BLAST PRIMER
NM_001354573.2
BLAST PRIMER
NM_001622.4
BLAST PRIMER
External Database
HGNC NCBI Ensembl UniProt OMIM GTEx

Secondary Structure

MANE Select
NM_001622.4
Sequence length
1596 nt
GC Content
0.5382

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-558.2 kcal/mol
Thermodynamic ensemble
Free Energy: -589.21 kcal/mol
Frequency: 0.0000
Diversity: 493.04
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...........((((((((((((.((((((...........))))))....((((((((((((.(.((((...(((((((..((((......)))).)))))))...((((...(((((...(((((((.....)))))))(((((((((((((.((.(((((((.(.(((((.((((.....(((((...))).))..)))).)).))).))))))))(((..((((((....(((.....)))........((((((((....((......)).....))))))))...((((((((.((....)).)))).))))))))))..))).)))))))).........)))))))((((((...(((((((.(((((..((((..(.(.((....)).).)..))))..))))).))).)...)))...)))))).)))))....))))(((.(((((....(((.((.((((...)))))).)))....)))))..))))))).).)).)).))))))))(((((((((((((((((.((((..((((.((.....((((((((....((.((....)).))....))))))))...)).))))......(((((((((..(((((((((((.....((.((((((..((((.((((((.((...(((((.((.....))......(((...))).((((((..((((((((..((((((((((((((..((.....))..))).)))((......))....))))))))....)))))))))))))))))))...)).)))))).))))(((((....)))))..(((((...))))))))))).))(((((..((.((........)).))...)).))).((((((((....)))).))))((((.(((.((................)).))).))))....)))))))))))..............(((..((((.(((((..(.(((....)))).))))).)))).)))((((........))))((((((((....))))))))....)))))))))..((((....((((((((...((((((((......((.((.((((.((((.((((......))))..)))).)))).)))).........))))))).).....))))))))...((((..((((....))))..))))))))((((((((.((((((.............))))))))))))))))))...)))))))))).((((.((.((((.((....)))))))).))))...............)))))))...............(((....((((((..((((((((.(((..(((((((((((((((......)))))).(((((...)))))((((......))))....))))))))).))).)))).))))((..(((((...........)))))..))..))))))...))).)))))))).)))).((((((.....((((.........)).))......(((((((.........))))))).))))))...
Thermodynamic Ensemble Prediction
...........((((((((((((,((((((...,...,...}}}))}.,{{(({.,,{|||{,{(((({,{{{(((({({,,.,,.(((((((((.{{((((((((((,(({((({{{{..,(((((((.....)))))))|((((((((((((.{{.(((((((.(.(((((.((((.....({({{...})),,,..)))).)).))),,)))))))(((..((((((....(({,....})},.......((((((((....((......))..,,.))))))))..,((((((((,({...},).))))}}}))))))))..))).}})))))).........))))))}((((.{,.((((....))))...).).))))})},)}})).}))))))))).|..|.}},,)).)))}{{{{...{{{|{{(|,....,,,},.(((.(((((....(((.{{.((({...})))}}.)))....}))))..)))||||,}{|,{||.,{||||||{{{|.,,{{{,,.....))},.,({((((.{...((((((((((,,.{{..,)}...)))))))))).,||.|||}.,}.{{{||,..{|||}{,,,,,..|||||((((((.....,{.{(((((,{((((.((((((.((.,.(((((.({...||}}......{((,,,,,,.((((((..((((((((..{{{{((({,,,.|||.(({..{{|,...,}})))})..,,,{||....,}))))))....))))))))))))))))))).,.)).)))))).))))||{{(,,,.||}||,,({(((...,}}}})))))),))|{|||,,||,|,........||{||...||..}}.((((((((....)))).)))){||{.{||,||,......,,,,,,},,)),))),)))},,..))))))))))).}}}}|||}}}|..{{{..((((.(((((..{.(((....)))}.))))).)))).|||((((........}}}|((((((((....))))))))|{({.{{((({....))}}})))|{((((((...{(((((((......||.({,{{||,|{((,|{{{|,.,,,))})},)))),)))},)}|,....,,...))))))).)}....))))))}},|||||,.|||{||{...|||||{|{||,||||||,|(((,(((.,,(((,,(((,((({{,((((((....)))))).||}|||.{|||..})).,.))))))}((((.({...}).)))).............{{{,...,}}},..{{{{{{{..|.((..((((...))))..)}.|..}}}}))}||||||||||||||...,{{|,||||,,{{{.{...{||{((((......)))))}}.,})})))})})})})})))))))||}}|||||}}}}},.....,}}}),,)),.)))),..},}},.)))))))),,))).((((((...{.(({(.........}),))......(((((((.{{....,,))))))).))))))...

Transcripts

ID Sequence Length GC Content
NM_001354571.2 CUACCUUUCCCAGCAGAGCACCUGGGUUGGUCCCGAAGCCUCCAACCAC… 1577 nt 0.5460
NM_001354572.2 CUACCUUUCCCAGCAGAGCACCUGGGUUGGUCCCGAAGCCUCCAACCAC… 1571 nt 0.5455
NM_001354573.2 CUACCUUUCCCAGCAGAGCACCUGGGUUGGUCCCGAAGCCUCCAACCAC… 1490 nt 0.5483
NM_001622.4 CUACCUUUCCCAGCAGAGCACCUGGGUUGGUCCCGAAGCCUCCAACCAC… 1574 nt 0.5457
Summary

The protein encoded by this gene is a negatively-charged serum glycoprotein that is synthesized by hepatocytes. The encoded protein consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several processes, including endocytosis, brain development, and the formation of bone tissue. Defects in this gene are a cause of susceptibility to leanness. [provided by RefSeq, Aug 2017]

Forensic Context

AHSG is a validated mRNA marker specifically associated with liver tissue identification. It was identified as part of a panel of biomarkers (including AHSG, AMBP, and VTN) used to detect liver tissue in post-mortem samples through multiplex RNA analysis . The assay demonstrated high specificity, correctly identifying liver tissue in individual samples without cross-reactivity with other organ tissues. Additionally, the method showed robust sensitivity, reliably detecting liver tissue even in highly diluted lysates (1:10,000 dilutions, corresponding to 2 ug of tissue) and in complex mixtures containing up to four components

Genomic Tracks
Track Image