Basic Information
Symbol
AIF-1
RNA Class
mRNA
Alias
allograft inflammatory factor 1
IRT-1
AIF-1
Em:AF129756.17
IBA1
interferon gamma responsive transcript
ionized calcium-binding adapter molecule 1
IRT1
protein G1
G1
Allograft inflammatory factor 1
Ionized calcium-binding adapter molecule 1
Protein G1
Location (GRCh38)
6:31615217-31617021
UCSC Genome Browser
Transcripts
Secondary Structure
MANE Select
NM_001623.5
Sequence length
655 nt
GC Content
0.4779
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-186.6 kcal/mol
Thermodynamic ensemble
Free Energy:
-199.01 kcal/mol
Frequency:
0.0000
Diversity:
154.7
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((((.....(.((((.(((......((((.((((........))))))))((((.((..(((((((((...(((.(((((((..(((.(....).))).....(((((((........(((((...(((((...((((((......))))))...)))))(((.(.((....)).).)))..)))))....(((((((.((......))..)).))))).(((.((((....((.((((((((............))))))))..))....))))...)))((((....))))..)))))))......))))))))))......(((((.....))))).....(((((..........((((((......))))))))))).))))))))).))))))..(((...((((((((((((..((.((........)).))))))))........((((........))))......))))))..)))....(((....)))))))))))..)).)))))((((((......((((.......))))...))))))....(((..((.(((((((((......(((....)))....)))))......((((..((....))..)))).............)))).)).))).
Thermodynamic Ensemble Prediction
.(((((((..,..{.((((.(((.,....((((.((((........)))))))),{{||((.,(((((((((...(((.((((((({.({(,,,,..,.))),....(((((((.....{{{({,,...,(((((...((((((......))))))...))))){||,,.((...,||.,.}}}..}}})}....((((({{..{.,....}},.)}.))))).(((.((((....((.((((((((............))))))))..))....))))...)))|{{,,,..)})),,)))))))....}.}))))))))).....{((({(.,,.,)}}}}.....(((((,.........{(((((......))))))))))).))))))))}.|||||}..(((,,.{{{{|||||{{{..||,|{||....,.}),)))}||||........((((........))))......}})}),..}))....(((....)))))))))))..))}}}))|((((((......((((.......))))...)))))),.,,(({..({.(((((((((......(((....)))....)))))......{(({..{{....))..))}}.,,..........}))),)).))).
Summary
This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. [provided by RefSeq, Jan 2016]
Forensic Context
No forensic context available.
Genomic Tracks
