Basic Information

Symbol
GNAS
RNA Class
mRNA
Alias
GNAS complex locus NESP55 NESP GNASXL GPSA SCG6 SgVI secretogranin VI G protein subunit alpha S guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1 AHO AIMAH1 C20orf45 GNAS1 GSA GSP PITA3 POH protein ALEX protein GNAS protein SCG6 (secretogranin VI) adenylate cyclase-stimulating G alpha protein alternative gene product encoded by XL-exon extra large alphas protein guanine nucleotide regulatory protein Protein ALEX Alternative gene product encoded by XL-exon Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Adenylate cyclase-stimulating G alpha protein Extra large alphas protein XLalphas Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Neuroendocrine secretory protein 55 EC 3.6.5.-
Location (GRCh38)
20:58839718-58911192 UCSC Genome Browser
Transcripts
NM_000516.7
BLAST PRIMER
NM_001077488.5
BLAST PRIMER
NM_001077489.4
BLAST PRIMER
NM_001077490.3
BLAST PRIMER
NM_001309840.2
BLAST PRIMER
NM_001309842.2
BLAST PRIMER
NM_001309861.2
BLAST PRIMER
NM_001309883.1
BLAST PRIMER
NM_001410912.1
BLAST PRIMER
NM_001410913.1
BLAST PRIMER
NM_016592.5
BLAST PRIMER
NM_080425.4
BLAST PRIMER
NM_080426.4
BLAST PRIMER
External Database
HGNC NCBI Ensembl UniProt OMIM GTEx

Secondary Structure

MANE Select
NM_000516.7
Sequence length
1854 nt
GC Content
0.5620

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-635.6 kcal/mol
Thermodynamic ensemble
Free Energy: -669.07 kcal/mol
Frequency: 0.0000
Diversity: 507.54
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....(((((.(((((..((((...((((((((..((((.((.((.(((.....))))))).))))..))).(((((((((.(........).)))))))))(((.....)))........((((((((((.(((((((((...((((.(.(((...))).).))))...))))))...(((((((((.((((.((..(((((.(((......))).))))).))..)))))))).((((((....).)))))((.((((((((.((((........)))).))(((((((.((.(((....((....((.((((((((((...........))))))..)))).))....))....))))).))).).))).................((((((.((((..((....((.(((((...)))))..)).))..)))).)))))))))))).)).......)))))((((.((((((....((((((....)).))))....))))))))))...)))..)))))).)))).))))).)))))))))..))))).((((.(((((((....(((..((....((((((....................(((((.((((...(((((((((((((((.(......)))))).....(((.(.((((((((.(((((.((((....((((.(((.....))).))))(((((..(((.((...((((((((.(((((((((((........((((........))))..)))))))..))))(.(((((((((((((......((((....)))).((((..((...((((....))))...))))))....((((.....)))).))))))).....)))))))......((((((((.((......)).).)))))))(.((((((((..(((....))))))))))).)..))))))))))))))))))))))..)).))))))))))).).)))...))))).)))))...))))))))).....(((..((((((((((....))))))).)))..))).........((((..(((....)))..)))).........))))))...))(((((((....))).))))((((((......)))))))))...))))))).))))((((.((((........)))).))))(((((((.((((.(((((((.((..(....)..))...)))))))..)))).......(((((((.((((...((((.((((.(((..((.(((((((((.(...((......))..)))))))............))).))..))))))).))))....(((.(((((..((((((((.((..(....)..)).))))))))..))).)).)))...(((((((((((.(((.(((((((..(((.....))))))).)))...))).)))....))).)))))....((((((((..(((((((((.................((((((((((((((((...............))))))).(((((.(((((((((((......)))..))))))))...((((....((.(((.....))).))..))))((((......))))......))))).((((((.......))))))...)))))))))(((((................)))))......))))))).))(((...)))...............)).))))))...........................................)))).))).))))............................))))))).....
Thermodynamic Ensemble Prediction
.(({(((((.(((({.,((((..,((((((((.,({{,,{|.||||||.....|}|||||{|||,.,||}.||||||||(,(,.,,..,.}.)}))))||||{|,,},}}}.....,,,.((((((((((.((((((((({,.(((({..((({{.{||.|.|,||{.{|||||,.....(((((((.((((.(,,.(((((.(((......))).))))).),,.)))))))).||||,}}}}}).))),).|.}}},,,))}}}.|}}}}.,..,))},))((({(((.({{(((..{.((.{..((.((((((((((...........))))))..)))).))..,.)).,..))))}.))),).))),................((((((.((((..((....({.(((({...)))))..)).))..)))).)))))))}}|||{||{...,}})))}.((((.((((((....((((((....)),})))....))))))))))...)))..)))))).)))).)))}}.)))))))))..))))).((((.(((((((.,..(((..{{....{{((((.............,,}}...(((((.((((...(((((((((((((((.(......}))))).....(((.(.(((((((,,(((((.((((...,((((.(((,,,..|||,}}}}|{|{|,,|,{.{{.|,{,||||||.{{(((((((((........((((........))))..)))))))..}}}}{{(({{{{(((((((..,..,{|{(,...}|||.((((,.,,...{|||.,..||))...},)))),,..((((,...})))).))))))){{{{{.{{{,||..,,,.((((((((.((......)).).))))))),.,((((((,,,(((....))))))))))},}}})),))))),}}))))),,))))..)).))))))))))).).)))...)))))}}}))).,.)))))))))...,.{((,.({((((((((....)))))))}})),.|}|,|.......((((..(((....)))..))))........}}})}}},,,}|{(((((,....})),,)))|(((((......))))))))).}.))))))).))))((({.(({(.,,.....}|||.|}}|||||,.({(,(({(((((((,{{.,,....}..})..,)))))}}..,)))))}..{{(((((((....,..,(({(.{(((,({(,{({.,(,((((((.,...,{.....,,}..,)))))),.,},,...},,}}}.)}.}))}||||.||}}{{,|(((.(((((.,((((((((.((..(....)..)).)))))))).,))).)).)))}}..|},}|||{{{.{{{.{,||||||.{{(...,.}}}|},,.}}}.,,))}|}||{,,..{(({....})))((((({,,.,({(((((((.................((((((((({{{{(({.,|,....,,.....}}}}))).(((((.(((((((((((......)))..))))))))...((((....{(.{{{.....))).))..))))((({......})))......))))).{{((((.......))))))...)))))))))(((((................)))))......)))))))}),,{{...,}}...............}),)))})}..........................,...,..........}}})})})))}})),............................)))))))},...

Transcripts

ID Sequence Length GC Content
NM_016592.5 AGUCUCCUCUGUCCUCUCCCAGGCAAGAGGACCGGCGGAGGCACCUCUC… 2551 nt 0.5539
NM_080425.4 AGACUCCAAAUCAGUCAGGGAGAGGAGUGGAAGGAGCCAAAACGUCCCU… 4027 nt 0.5890
NM_080426.4 AGCAGCUCCCGCAGCUCCUGCUCUGGUCCGCCUCGGCCCGGCGGCGGCC… 1809 nt 0.5594
Showing 11 to 13 of 13 entries
Summary

This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]

Forensic Context

No forensic context available.

Genomic Tracks
Track Image