Basic Information
Symbol
ALOX5AP
RNA Class
mRNA
Alias
arachidonate 5-lipoxygenase activating protein
FLAP
five-lipoxygenase activating protein
MK-886-binding protein
arachidonate 5-lipoxygenase-activating protein
Arachidonate 5-lipoxygenase-activating protein
Location (GRCh38)
13:30713478-30765072
UCSC Genome Browser
Transcripts
Secondary Structure
MANE Select
NM_001629.4
Sequence length
869 nt
GC Content
0.4707
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-247 kcal/mol
Thermodynamic ensemble
Free Energy:
-264.52 kcal/mol
Frequency:
0.0000
Diversity:
220.8
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((((......))))))))...((((((((((((....((((.((((((.((((......((((..........((((((...(((((......(((..((((((..(((......((((.((((..((((.........))))....)))).)))).....)))..((((((((((((((((...((((((.(.((....)).))))))).((((.......))))......(((..((((.(((((((..((((........((((((((((((.((((((((...)))))))))).(((....)))((((((.((((((((((((((((..((((...))))))))))...))))))...)))).).....))))))))))))....)))........))))..)))))))))))..)))..)))))))....))))).)))).................(((.(((((.....))))))))..................))))))..))).(((((...((((..((.(((....................))))).)))).)))))............)))))))))))..)))).....)))))))))).))))....)))))))...(((((((((((.........)))))))))))))))).((((((((...(((..(((((....(((((((((.((..((((((((((.((........)).).))).))))))..))..))))...))))).((((((((((((.......(((....((((.((.(.(((....))).).)).))))...)))........))))))))))))))).)).))))))))))).
Thermodynamic Ensemble Prediction
.,,,.,(((((((((((.,{(((((((((((((((((....((((.((((({,((((......{{({........,,((((((...{{,{({{{,{{((({,{,{|||..........,{{{(,((((..{(({.,....,,,)}))...,)))},))})..{|||||||,,,(((((((((((({,,,({({((.{.{|,..,||.||}}}}}.{|{|,,.,,,,|}}}......{,,..||||,(((((((..((((..,.....((((((((((((.((((((((...)))))))))),,{{....}||((((({.((((((((((((((({.{((({...)))}})))))...))))))..,}}}}.},,,.}))))))))))))....)))........))))..))))))),,,)}}))),}))))}},..}})),})}))}}.................{((.(((((.....)))))))}.,|||,...........,}},}|}..}}}.(((((...((((..,..{{{.................,..))},,.)))).)))))............,,,,,)))))},}))}).....)))))))))).))))....)))))))...{((((((((((,,....,,.}))))))))))))))).))))).,...})))),})))},...(((({({{{.{{..((((((((({.,,.......,)}.},)))},)))}}..},..}}})...))))).((((((((((((.......(((..,.((((.((.(.(((....))).).)).))))...)))........))))))))))))..,.,,.,,,....,},,.
Transcripts
| ID | Sequence | Length | GC Content |
|---|---|---|---|
| NM_001204406.2 | AUCUGGGCAUUUGGAGGUGAAGGGGUCACAGCUCUGGCAAAGAUGGGGU… | 1218 nt | 0.4828 |
| NM_001629.4 | CUGUACAGGGCAGGUUGUGCAGCUGGAGGCAGAGCAGUCCUCUCUGGGG… | 869 nt | 0.4707 |
Summary
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
Forensic Context
No forensic context available.
Genomic Tracks
