Basic Information
Symbol
IL37
RNA Class
mRNA
Alias
interleukin 37
FIL1
FIL1Z
FIL1(ZETA)
IL-1H4
IL-1RP1
IL-1F7
interleukin 1, zeta
interleukin-1 homolog 4
interleukin-1-related protein
interleukin 1 family, member 7 (zeta)
IL-1H
IL-23
IL-37
IL1F7
IL1H4
IL1RP1
interleukin-37
FIL1 zeta
IL-1 zeta
IL-1F7b (IL-1H4, IL-1H, IL-1RP1)
IL-1X protein
IL1F7 (canonical product IL-1F7b)
interleukin 1 family member 7
interleukin-1 superfamily z
interleukin-23
Interleukin-37
IL-1X
Interleukin-1 family member 7
Interleukin-1 homolog 4
Interleukin-1 zeta
Interleukin-1-related protein
Location (GRCh38)
2:112911165-112918882
UCSC Genome Browser
Transcripts
Secondary Structure
MANE Select
NM_014439.4
Sequence length
864 nt
GC Content
0.4815
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-281.3 kcal/mol
Thermodynamic ensemble
Free Energy:
-296.28 kcal/mol
Frequency:
0.0000
Diversity:
189.82
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...........((((((..(((........)))..((((.((((((((((((.(.((((..((((....)).))..)))).)..))))))))))))....(((((((((((((((.....))))))))..))))))).(((....)))))))..))))))(((((....((((((.....((((((............))))))((((((.....((((((((.(((.((((((((......(((((....((((((..((((((((((((....)))))......(.((((...(((.......)))...)))).)))))))).(((((((((........)))))))))..(((((((............)))))))............((.(((((((((((((((((((...((((((....))))....))...))))))))).((....)))).))).))))).)).......))))))..(((((........)))))((((....(((...))))))).(((((((.......))))).))....(((((((((((((((((....)).....))).))))))..)))))).......))))))))).)))))))........))))).)))))))))(((((((((..(((((((.((((...........)))))))))))..))))))))).......((((.((....(.((((...(((((.......)))))...)))).)....)).)))))))))).(((((((...(((.(((((........))..))).)))...)))))))..((((.((.....)).))))..............)))))...
Thermodynamic Ensemble Prediction
.{{{..(((.{((((((..(((........)))..}}||}||{(((((((((.(.((((..((((....)).))..)))).}..)))))))))}||....((((((({(((((((.....)))))))}..))))))){(({,...|||}}},..}}}}})}|||,....((((((,,,,.((((((............))))))((((((.....((((((((,((.{((((((((,.....(((((..,,{(((((..(((((((.(({(,{,,.|..,......{}||||.,,|,,......,||,...)))}.,))))))).(((((((((........)))))))))..(((((({..,,....,.,,})))))}............,,.||{(((({,{{||||||{,..{((((((....))))},..||{{{||,||||||.((....))..))))))))))})).......)))))).,(((((.{....}.))))){(((...,(({...}}}}))).{{(((((.......))))).}}....(((((((((((((((((....)).....))).))))))..))))))..,....))))))))).)))))})........))))).)))))))))(((((((((..(((((((.((((......,....}))})))))))..))))))))).......,{{({((,...(.{{{{...{{{{{.,,,,..))))}.{,||||.,.,}}))},,,,)))))).(((((((...(((.(((((........))..))).)))...)))))))..,{,,.,,....,||..,,...,......})),,}.,,,...
Transcripts
| ID | Sequence | Length | GC Content |
|---|---|---|---|
| NM_014439.4 | AAGUAAAGGAUCCUGAGAACUGAAGGCAAACAGAGCUCCAGGAGUCCAA… | 864 nt | 0.4815 |
| NM_173202.2 | AAGUAAAGGAUCCUGAGAACUGAAGGCAAACAGAGCUCCAGGAGUCCAA… | 801 nt | 0.4732 |
| NM_173203.2 | AAGUAAAGGAUCCUGAGAACUGAAGGCAAACAGAGCUCCAGGAGUCCAA… | 681 nt | 0.4787 |
| NM_173204.2 | AAGUAAAGGAUCCUGAGAACUGAAGGCAAACAGAGCUCCAGGAGUCCAA… | 744 nt | 0.4879 |
| NM_173205.2 | AUGUCAGGCUGUGAUAGGAGGGAAACAGAAACCAAAGGAAAGAACAGCU… | 652 nt | 0.4663 |
Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Forensic Context
No forensic context available.
Genomic Tracks
