Basic Information

Symbol
IL6
RNA Class
mRNA
Alias
interleukin 6 IL-6 BSF2 HGF HSF interferon, beta 2 interleukin 6 (interferon, beta 2) BSF-2 CDF IFN-beta-2 IFNB2 interleukin-6 B-cell differentiation factor B-cell stimulatory factor 2 CTL differentiation factor hybridoma growth factor interferon beta-2 interleukin BSF-2 Interleukin-6 Hybridoma growth factor Interferon beta-2
Location (GRCh38)
7:22725884-22732002 UCSC Genome Browser
Transcripts
NM_000600.5
BLAST PRIMER
NM_001318095.2
BLAST PRIMER
NM_001371096.1
BLAST PRIMER
External Database
HGNC NCBI Ensembl UniProt OMIM GTEx

Secondary Structure

MANE Select
NM_000600.5
Sequence length
1127 nt
GC Content
0.4250

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-305.1 kcal/mol
Thermodynamic ensemble
Free Energy: -325.18 kcal/mol
Frequency: 0.0000
Diversity: 221.92
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....((((....((((....((((..((.((((...)))).))))))(((((((((.((((..((((.....(((.((((((((.((((....(((((.(((((....(((.(((((...((((((..((..(((((((((((((............)))).))))...........))))).))..))).))).)))))..(((((((((.....((((((........)))))).......((((..(((......))).))))..)))))((((((.((....)).))))))))))...)))....))))))))))(((........)))..((.((....)).)).((((..(((((((....))).))))...))))..)))).).))))..))).)))..))))..)))).)))))))))(((((((((..((((.(.(...(((((((..(((((((((((((((.((......))(((((((((((((((((.......(((.((.......((((((((......(((...........)))....................((((........((((((..........)))))).........)))))))))))))).))).......)))).)))))))))))))(((((((.(((((((..((((((((((((((....((.......))..)))).))))))...))))))))....))).)))))))....(((.(((....))).)))((((((.((..((((.....((((((....))))))...)))).)).)).))))..)))))))))(((((....))))).........(((((.(((((((..(((.(((.......))).)))..))))))).))))).((((...))))...((((...))))....((((((((((((......(((.((......)).))).........))))))))))))))))))..))).)))).).).))))..))))))))).....)))).........(((((((....))))))).(((((((((....)))))))))....((((......))))......))))..............
Thermodynamic Ensemble Prediction
....((((....((((....((((..((.((((...)))).))))))(((((((((.((((..((((.....(((.((((((((.((((,,,,(((({{((((({(..(((,(((((.{.((((((..((..(((((((((((((............)))).))))...........))))).))..))).))).))))).,{{.{{({{{,,{..((((((........)))))).......{{{,..(((......))),))))...)))}((((((.((....)).)))))),|.....)}}....))))))))))(((........)))..{{.,(,...}},)).{(({..(((((((....)))},)))...)))}..)))).).))))..))).)))..))))..)))).)))))))))(((((((((..((((.(.(...(((((((..((((((((((((((({(({{{...||(((((((((((((((((.......(((.((.......((((((((......(({...........}}}............,,......((((...,,,..((((((.,......}.)))))).........)))))))))))))}.))).......)))),})))))))))))}.,||,||}|||{{{(,,(((,((((((((((....((.......))..)))).))))))..,}}}},}}}....||}.},}}}},....(((.(((....))).))){{||||.||..{(((.,{,,((((((....))))))...}}}).)).)}.,,}}..))))))))),{{{{....}}}},........,{((((.(((((((..(((.(((.......))).)))..))))))).})))}|.,{,...,}}|||.{{{{...}})).,,.((((((((((({..,.{{({{.{({,,...}),)),...,.}}}.))))))))))))))))))..)))}}))).).).))))..))))))))).....))))....{{{{.(((((({....})))))}.||||{{||{|||||||,}})))}}}.{(((......)))}......))))..............

Transcripts

ID Sequence Length GC Content
NM_000600.5 AUUCUGCCCUCGAGCCCACCGGGAACGAAAGAGAAGCUCUAUCUCCCCU… 1127 nt 0.4250
NM_001318095.2 AUUCUGCCCUCGAGCCCACCGGGAACGAAAGAGAAGCUCUAUCUCCCCU… 936 nt 0.3942
NM_001371096.1 AUUCUGCCCUCGAGCCCACCGGGAACGAAAGAGAAGCUCUAUCUCCCCU… 1058 nt 0.4083
Summary

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Aug 2020]

Forensic Context

No forensic context available.

Genomic Tracks
Track Image