Basic Information

Symbol
MMP7
RNA Class
mRNA
Alias
matrix metallopeptidase 7 PUMP-1 matrilysin matrix metalloproteinase 7 (matrilysin, uterine) MMP-7 MPSL1 matrin matrix metallopeptidase 7 (matrilysin, uterine) matrix metalloproteinase-7 pump-1 protease uterine matrilysin uterine metalloproteinase PUMP1 Matrilysin Matrin Matrix metalloproteinase-7 Pump-1 protease Uterine metalloproteinase EC 3.4.24.23 EC 3.4.24
Location (GRCh38)
11:102520508-102530853 UCSC Genome Browser
Transcripts
NM_002423.5
BLAST PRIMER
External Database
HGNC NCBI Ensembl UniProt OMIM GTEx

Secondary Structure

MANE Select
NM_002423.5
Sequence length
1119 nt
GC Content
0.4334

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-313.3 kcal/mol
Thermodynamic ensemble
Free Energy: -337.87 kcal/mol
Frequency: 0.0000
Diversity: 284.99
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...((((..(((((.(((((((((.......))).))))).(((((...(((......))))))))(((.(((((((((.((((((((((((..(((...))))))))).....)))))).)))).((((((((((...((....)).))))))........(((((((((...)))))).)))))))...........((((.((((((((((.(((....((((((((.(.....).))))))))...........(((.((((((..(((((.(((((......................))))))))))....)))))).)))........(((((....))))).(((...(((....)))...)))........((..(((...........)))..))..((((........))))...(((....)))...)))))))))).)))..))))..((.(((((((((((.....((((((((..(((((((.((.(..(((((((.........((((..((((..(((.(((((.(((((((((...((..(((((((.....(((((((((((.((((...(((((...))))).(((((((((...))).)))))).))))))))..))))).)).(((((.(((((...((((......))))....))))).)).)))...)))))))..))..)))))..))))...))))))))))))..))))))))))).((((.....))))...).)).)))))).....)..))))))))..((((((.....(((((((((((((((((.(((((....(((((..(((............)))))))).((..(((((((((.............)))))(((.(((((...(((......)))...))))).)))..))))..))..)))))...(((((................)))))...)))))))))))))))))((((.((....(((((.....)))))...)).))))...........)))))).....))))).)))..))).))..........)))))))).((((((((...))))))))).)))))..)))).
Thermodynamic Ensemble Prediction
...{{({..(((((.{(((((((({(....))}),))))).(((((.,|({(,,....|}}}||}||,|||||((((((.((((((((((((..(((...))))))))).....)))))).)))))}{(((((({({{{((,....},||}}}|{{...,{{((,((((((...)))))).,,,...............((((.((((((((((((((....,{.,{{{{,({{{{...,|||||{{{,,.,{,{{{.((({,,,(({..,{(,,,((((,.,.....,.,,}}.,.,},}}}),)))))))}}}}})),,))}))|........((({{....,}}}}.(({...|||...,||,..{|||....}}},,|},{{(,,,....,,,.}||..||..((((........))))...{{{.,,,}))...)))))))))).)))..))))..||}||{|{||||(({{{..((((((((..{((((((.((.(,.(((((({,.,||||,..((((((((.((..(((((........))))}...(((((((((........))))))))))))))))))),{|||..{((..(((((((({{((((((..{(.{.(((((((...(((({....(((((.(((((.,{((((......)))),...))))).)).)))....})))))))))))},))..)))).))))))))))).))).,|,||}}}}))).{(((.....)))}...).)).))))))........))))))))..}}||}.....,(((((((((((((((((..((,({,{{(((({..{((......,,,...}}.,}})).((..((((({(((.............))))}(((.(((((...(((......)))...))))).))}.}))))..))..,,,,,...(({,,..,}.....,,}}}}},)),)}..)))))))))))))))))|(((.((....(((((.....)))))...)).))))}}}}}.}}}}}))||{|{{.{..,,}},))))})))}},.,,...,{{.....}}}..{(((((({...)))))))),.)))))..})}}.

Transcripts

ID Sequence Length GC Content
NM_002423.5 ACCAAAUCAACCAUAGGUCCAAGAACAAUUGUCUCUGGACGGCAGCUAU… 1119 nt 0.4334
Summary

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016]

Forensic Context

No forensic context available.

Genomic Tracks
Track Image