Basic Information
Symbol
MUC1
RNA Class
mRNA
Alias
mucin 1, cell surface associated
CD227
PEM
ADMCKD
ADMCKD1
MCKD
MCD
KL-6
EMA
Ca15-3
epithelial membrane antigen
mucin 1, transmembrane
medullary cystic kidney disease 1 (autosomal dominant)
ADTKD2
CA 15-3
H23AG
MAM6
MCKD1
MUC-1
MUC-1/SEC
MUC-1/X
MUC1/ZD
PEMT
PUM
mucin-1
H23 antigen
breast carcinoma-associated antigen DF3
cancer antigen 15-3
carcinoma-associated mucin
episialin
krebs von den Lungen-6
peanut-reactive urinary mucin
polymorphic epithelial mucin
tumor associated epithelial mucin
tumor-associated epithelial membrane antigen
Mucin-1
Breast carcinoma-associated antigen DF3
Cancer antigen 15-3
Carcinoma-associated mucin
Episialin
Krebs von den Lungen-6
Peanut-reactive urinary mucin
Polymorphic epithelial mucin
Tumor-associated epithelial membrane antigen
Tumor-associated mucin
CD227 antigen
Location (GRCh38)
1:155185824-155192916
UCSC Genome Browser
Transcripts
Secondary Structure
MANE Select
NM_002456
Sequence length
1199 nt
GC Content
0.5513
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-446.4 kcal/mol
Thermodynamic ensemble
Free Energy:
-464.18 kcal/mol
Frequency:
0.0000
Diversity:
358.67
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..........(((((((.(((.((((...((((....((((((...((((.((((((.(((....(((((((((((((.(((((..............((....))..((((((((.(..((((.(((...(((((((((((.((.((((((((((...)))))))..(((((((((((((.((..(((((...(((((((........))))))).......)))))..))))))))))))))).......((((.(((((((.....((((((((.(((((....((((.(((.((.((........))...)).)))))))(((((((..(((((((...)))))))))))))).....)))))..))))))))(((.(((((...(........)...))))).)))...((.((((.(((.((((.....((((((...))))))....))))))))))).))))))))).)))).................(((((..(((..(((.....((((((((........)))))).))...))).).))..))))).......((((......))))(((((((..(((.(((((...(.((((..(((.(.((((..(((((((((....(((((....(((((.............((((((((((.(((............)))))))))))))))))).....))))))))))))))..)))).))))..)))).)..))))))))..))).)))).(((((..(((((((((((.((((.(((..((((((...))))))...)))..))))))((((.((.(((....))).)).)))).........((((((((((......))))))..)))).)))))))))))))).(((((..((((((...((....))....))))))..)))))...))))).)))))))))))..)))..))))..).))).)))))))))).)))).))))(((((....))))).(((((((.(((((((....((((.((.(((((....))))).))))))....)).))))).))))))).)))))..)))))))))..)))).))))))...))))))).).))).(((.((.(((((......))))).)))))..)))).)))........((((....))))........
Thermodynamic Ensemble Prediction
..,,,,,..,(((((((.{(({{((({,.,{{{....((((((...{(({.((((((.(((....(((((((((((((.(((((.,,,..........((.,,,|}..,,{{((((,(..(({(.{{{.,.(((((((((((.{{.,{{(((((((...}}}||||,,(((((((((((((.((..(((((...(((((((........))))))).......)))))..))))))))))))))}.......((((.(((((((.....{(((((((.(((((....{,{{,(((.{{.{{,,,,....},...}}.,},}}}}((((({{{{(((((({...}))))))))))))).....}))))..)))))))|(((,(((((...,........}...)))))})))...((.((((.((,{((((....,((((((...))))))...,))))))))))).))))))))).))))........{,......,(({((,,{{|,,{{{.....{{((((((.,,...,,)))))).))},||||,||}|,.,}}}}.,,,.,,|(((....,,)))}{((((((..(((.(((((.,.{.((((..(((.(.((((..(((((((((..,,(((((....(((((.............|(((((((((.(({.,........}.))))))))))))||)})}.....))))))))))))))..)))).)))}..)))).},.))))))))..))).)))}.((((({.,,||||||({{.((((.(((..((((((...))))))...)))..))))))|{{{.((.(((....))).)}.}}}}.,...,,,,((((((((((......)))))}.,,|||,|||||}}}}}||||}|{((({{((((((......{{{|,.....)))))})))))),}}),,},,)))}))})))),})))..))))..),))))}))))))))).)))).))))(((((....))))),(((((((.(((((((,.,.{(((.((.(((((....|)))).)))))}....}),))))).))))))).)))))..))))))))).,)))).)))))),..})))))).)}))).{{|,||,(((((......))))).}}|}}..}})),,}}.......,((((,...}})),}}}....
Transcripts
| ID | Sequence | Length | GC Content |
|---|---|---|---|
| NM_001204288.2 | ACCUCUCAAGCAGCCAGCGCCUGCCUGAAUCUGUUCUGCCCCCUCCCCA… | 1140 nt | 0.5605 |
| NM_001204289.2 | ACCUCUCAAGCAGCCAGCGCCUGCCUGAAUCUGUUCUGCCCCCUCCCCA… | 1094 nt | 0.5676 |
| NM_001204290.2 | ACCUCUCAAGCAGCCAGCGCCUGCCUGAAUCUGUUCUGCCCCCUCCCCA… | 1031 nt | 0.5684 |
| NM_001204291.1 | CGCUCCACCUCUCAAGCAGCCAGCGCCUGCCUGAAUCUGUUCUGCCCCC… | 1124 nt | 0.5596 |
| NM_001204292.1 | CGCUCCACCUCUCAAGCAGCCAGCGCCUGCCUGAAUCUGUUCUGCCCCC… | 1118 nt | 0.5653 |
| NM_001204293.2 | ACCUCUCAAGCAGCCAGCGCCUGCCUGAAUCUGUUCUGCCCCCUCCCCA… | 1077 nt | 0.5469 |
| NM_001204294.2 | ACCUCUCAAGCAGCCAGCGCCUGCCUGAAUCUGUUCUGCCCCCUCCCCA… | 1070 nt | 0.5710 |
| NM_001204295.1 | CGCUCCACCUCUCAAGCAGCCAGCGCCUGCCUGAAUCUGUUCUGCCCCC… | 968 nt | 0.5723 |
| NM_001204296.2 | ACCUCUCAAGCAGCCAGCGCCUGCCUGAAUCUGUUCUGCCCCCUCCCCA… | 1016 nt | 0.5699 |
| NM_001204297.2 | ACCUCUCAAGCAGCCAGCGCCUGCCUGAAUCUGUUCUGCCCCCUCCCCA… | 911 nt | 0.5653 |
Showing 11 to 20 of 23 entries
Summary
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
Forensic Context
No forensic context available.
Genomic Tracks
